ArticleStem cell reports2014
Sustained ERK activation underlies reprogramming in regeneration-competent salamander cells and distinguishes them from their mammalian counterparts.
Article in Stem cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 57 citations in OpenAlex.
- Article
- Sustained ERK signaling couples the injury response to organizer formation during Hydra head regeneration.Developmental biology · 2026Article
- An adult myogenic cell line of the Japanese fire-bellied newt Cynops pyrrhogaster.Scientific reports · 2024Article
- Amputation Triggers Long-Range Epidermal Permeability Changes in Evolutionarily Distant Regenerative Organisms.bioRxiv : the preprint server for biology · 2024Article
- ERK-activated CK-2 triggers blastema formation during appendage regeneration.Science advances · 2024Article
- Evolutionary Insights into the Relationship of Frogs, Salamanders, and Caecilians and Their Adaptive Traits, with an Emphasis on Salamander Regeneration and Longevity.Animals : an open access journal from MDPI · 2023Article
- Optomechanically Actuated Hydrogel Platform for Cell Stimulation with Spatial and Temporal Resolution.ACS biomaterials science & engineering · 2023Article
- The scaling of goals from cellular to anatomical homeostasis: an evolutionary simulation, experiment and analysis.Interface focus · 2023Article
- Senescent cells enhance newt limb regeneration by promoting muscle dedifferentiation.Aging cell · 2023Article
- An ERK-dependent molecular switch antagonizes fibrosis and promotes regeneration in spiny mice (Science advances · 2023Article
- Injury-induced MAPK activation triggers body axis formation inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- The planarian wound epidermis gene equinox is required for blastema formation in regeneration.Nature communications · 2022Article
- MAPK/ERK Pathway as a Central Regulator in Vertebrate Organ Regeneration.International journal of molecular sciences · 2022Review
- The retinal pigment epithelium: Development, injury responses, and regenerative potential in mammalian and non-mammalian systems.Progress in retinal and eye research · 2021Review
- Mathematical modeling of Erk activity waves in regenerating zebrafish scales.Biophysical journal · 2021Article
- Planarian stem cells sense the identity of the missing pharynx to launch its targeted regeneration.eLife · 2021Article
- Expression and Functional Characterization ofGenes · 2021Article
- Salamander Insights Into Ageing and Rejuvenation.Frontiers in cell and developmental biology · 2021Article
- Can laboratory model systems instruct human limb regeneration?Development (Cambridge, England) · 2019Article
- Shp2-Mitogen-Activated Protein Kinase Signaling Drives Proliferation during Zebrafish Embryo Caudal Fin Fold Regeneration.Molecular and cellular biology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In regeneration-competent vertebrates, such as salamanders, regeneration depends on the ability of various differentiated adult cell types to undergo natural reprogramming. This ability is rarely observed in regeneration-incompetent species such as mammals, providing an explanation for their poor regenerative potential. To date, little is known about the molecular mechanisms mediating natural reprogramming during regeneration. Here, we have identified the extent of extracellular signal-regulated kinase (ERK) activation as a key component of such mechanisms. We show that sustained ERK activation following serum induction is required for re-entry into the cell cycle of postmitotic salamander muscle cells, partially by promoting the downregulation of p53 activity. Moreover, ERK activation induces epigenetic modifications and downregulation of muscle-specific genes such as Sox6. Remarkably, while long-term ERK activation is found in salamander myotubes, only transient activation is seen in their mammalian counterparts, suggesting that the extent of ERK activation could underlie differences in regenerative competence between species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.