Evidence map›Paper›PMID 25068108›Full record

ArticleNeuroImage. Clinical2014

Linking DMN connectivity to episodic memory capacity: what can we learn from patients with medial temporal lobe damage?

Cornelia McCormick, Andrea B Protzner, Alexander J Barnett, Melanie Cohn, Taufik A Valiante, Mary Pat McAndrews

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05450822 (The BrainDrugs-Epilepsy Study), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05450822 recruitingnot on this mapstarted 2022, after this paper: background citation

The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy

TypeobservationalSponsorGitte Moos KnudsenRan2022 to 2031Enrolled550ConditionsEpilepsyArmsLevetiracetam, Levetiracetam Tablets, Lamotrigine tablet
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Frontiers of medicine · 2021
    Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cornelia McCormickKrembil Neuroscience Center & Toronto Western Research Institute, University Health Network, Toronto, ON, Canada ; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
Andrea B ProtznerDepartment of Psychology, University of Calgary, Calgary, AB, Canada.
Alexander J BarnettKrembil Neuroscience Center & Toronto Western Research Institute, University Health Network, Toronto, ON, Canada ; Department of Psychology, University of Toronto, Toronto, ON, Canada.
Melanie CohnKrembil Neuroscience Center & Toronto Western Research Institute, University Health Network, Toronto, ON, Canada ; Department of Psychology, University of Toronto, Toronto, ON, Canada.
Taufik A ValianteKrembil Neuroscience Center & Toronto Western Research Institute, University Health Network, Toronto, ON, Canada ; Department of Neurosurgery, University of Toronto, Toronto, ON, Canada.
Mary Pat McAndrewsKrembil Neuroscience Center & Toronto Western Research Institute, University Health Network, Toronto, ON, Canada ; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada ; Department of Psychology, University of Toronto, Toronto, ON, Canada.

Funding

Canadian Institutes of Health Research 97891
6 · The paper itself

Abstract

Computational models predict that focal damage to the Default Mode Network (DMN) causes widespread decreases and increases of functional DMN connectivity. How such alterations impact functioning in a specific cognitive domain such as episodic memory remains relatively unexplored. Here, we show in patients with unilateral medial temporal lobe epilepsy (mTLE) that focal structural damage leads indeed to specific patterns of DMN functional connectivity alterations, specifically decreased connectivity between both medial temporal lobes (MTLs) and the posterior part of the DMN and increased intrahemispheric anterior-posterior connectivity. Importantly, these patterns were associated with better and worse episodic memory capacity, respectively. These distinct patterns, shown here for the first time, suggest that a close dialogue between both MTLs and the posterior components of the DMN is required to fully express the extensive repertoire of episodic memory abilities.

Indexed as

Memory, EpisodicAdultAssociation LearningBrain MappingEpilepsy, Temporal LobeFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedNerve NetTemporal LobeYoung AdultEpisodic memoryFunctional connectivity patternsMedial temporal lobe epilepsyMediationStructural damage

Identifiers

PMID25068108
PMCPMC4110351

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.