ArticleIranian Red Crescent medical journal2014
Comparing Nigella sativa Oil and Fish Oil in Treatment of Vitiligo.
Article in Iranian Red Crescent medical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Interventions for vitiligo.The Cochrane database of systematic reviews · 2015Pooled it
- Role ofBiomedical reports · 2025Review
- Dietary Interventions, Supplements, and Plant-Derived Compounds for Adjunct Vitiligo Management: A Review of the Literature.Nutrients · 2025Review
- Use of complementary and alternative medicine in vitiligo: a cross-sectional survey.Archives of dermatological research · 2024Article
- Implementation of the vitiligo area scoring index in clinical studies of patients with vitiligo: a scoping review.Archives of dermatological research · 2023Article
- The Role of Nutrition in Immune-Mediated, Inflammatory Skin Disease: A Narrative Review.Nutrients · 2022Review
- The Therapeutic Effects ofEvidence-based complementary and alternative medicine : eCAM · 2022Review
- Bioactive Compounds for Skin Health: A Review.Nutrients · 2021Review
- A Review on Extraction, Characterization, and Applications of Bioactive Peptides From Pressed Black Cumin Seed Cake.Frontiers in nutrition · 2021Review
- Nigella Plants - Traditional Uses, Bioactive Phytoconstituents, Preclinical and Clinical Studies.Frontiers in pharmacology · 2021Review
- The effect of nigella sativa oil on the prevention of phlebitis induced by chemotherapy: a clinical trial.BioMedicine · 2019Article
- Role of Fatty Acids Intake in Generalized Vitiligo.International journal of preventive medicine · 2019Article
- Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone.Journal of pharmacopuncture · 2017Review
- A Review on the Cosmeceutical and External Applications ofJournal of tropical medicine · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitiligo is one of the autoimmune skin diseases that destroy the melanocytes of the skin. Moreover, its prevalence varies in different countries and regions.
objectivesThe aim of this study was to compare the effect of Nigella sativa and fish oil on vitiligo lesions of the patients referred to a dermatology clinic. MATERIALS AND
methodsThis randomized, double blind clinical trial was conducted in the dermatology clinic of the Imam Khomeini Hospital Ahvaz, Iran, from June to December 2011. We used a randomized simple sampling. From 96 patients with vitiligo, 52 eligible patients were selected and allocated to two groups with equal size. The study medications were applied twice a day by patients on their lesions. After six months, the improvement rate of lesions was assessed by the Vitiligo Area Scoring Index (VASI). Data were analyzed using SPSS v. 15; P value < 0.05 was considered as statistically significant.
resultsAfter six months, a mean score of VASI decreased from 4.98 to 3.75 in patients applying topical Nigella sativa and from 4.98 to 4.62 in those using topical fish oil. Most of the percent improvement observed in upper extremities, trunk, head, and neck of those who received Nigella sativa and head, neck, trunk, and feet of those who received fish oil. No adverse effect was reported by the patients.
conclusionsNigella sativa oil and fish oil were effective in reduction the size of patient's lesions; however, Nigella sativa was more effective in comparison to the fish oil. Therefore, using Nigella sativa with the major drugs in the treatment of vitiligo is recommended.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.