ReviewWorld journal of hepatology2014
Focal liver lesions detection and characterization: The advantages of gadoxetic acid-enhanced liver MRI.
Review in World journal of hepatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Pooled it
- Pooled it
- Deep learning reconstruction improves detection of focal liver lesions in hepatobiliary phase compared to conventional EOB-MRI.Frontiers in medicine · 2026Article
- Automatic Classification of Focal Liver Lesions Based on Multi-Sequence MRI.Journal of imaging informatics in medicine · 2025Article
- Case Report: Concurrent two adenomatoid tumors of liver.Frontiers in oncology · 2025Article
- Lesions hyper- to isointense to surrounding liver in the hepatobiliary phase of gadoxetic acid-enhanced MRI.European radiology · 2024Article
- Hepatobiliary phases in magnetic resonance imaging using liver-specific contrast for focal lesions in clinical practice.World journal of hepatology · 2022Article
- Application of Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) in hepatocellular carcinoma.World journal of surgical oncology · 2020Review
- Gd-EOB-DTP-enhanced MRC in the preoperative percutaneous management of intra and extrahepatic biliary leakages: does it matter?Gland surgery · 2019Review
- Does gadoxetate disodium affect MRE measurements in the delayed hepatobiliary phase?European radiology · 2019Article
- Comparison of gadoxetic acid versus gadopentetate dimeglumine for the detection of hepatocellular carcinoma at 1.5 T using the liver imaging reporting and data system (LI-RADS v.2017).Cancer imaging : the official publication of the International Cancer Imaging Society · 2018Article
- Gadoxetic acid disodium-enhanced MR imaging of cholangiolocellular carcinoma of the liver: imaging characteristics and histopathological correlations.European radiology · 2017Article
- Abdominal cross-sectional imaging of the associating liver partition and portal vein ligation for staged hepatectomy procedure.World journal of hepatology · 2017Review
- Contrast-Enhanced Magnetic Resonance Cholangiography: Practical Tips and Clinical Indications for Biliary Disease Management.Gastroenterology research and practice · 2017Review
- Latest developments in precancerous lesions of hepatocellular carcinoma.World journal of gastroenterology · 2016Review
- Gd-EOB-DTPA-Enhanced Magnetic Resonance Findings of a Giant Inflammatory Hepatocellular Adenoma: a Case Report and Review of the Literature.Journal of gastrointestinal cancer · 2015Review
- Disappearing liver metastases from colorectal cancer: impact of modern imaging modalities.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2015Article
- The value of liver resection for focal nodular hyperplasia: resection yes or no?European journal of medical research · 2015Article
- Noninvasive diagnosis of hepatocellular carcinoma on gadoxetic acid-enhanced MRI: can hypointensity on the hepatobiliary phase be used as an alternative to washout?European radiology · 2015Article
- Concurrent hepatic hemangioma and solitary fibrous tumor: diagnosis and management.Journal of surgical case reports · 2015Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since its clinical introduction, several studies in literature have investigated gadolinium ethoxybenzhyl diethylenetriaminepentaacetic acid or gadoxetic acid (Gd-EOB-DTPA) properties. Following contrast injection, it provides dynamic vascular phases (arterial, portal and equilibrium phases) and hepatobiliary phase, the latter due to its uptake by functional hepatocytes. The main advantages of Gd-EOB-DTPA of focal liver lesion detection and characterization are discussed in this paper. Namely, we focus on the possibility of distinguishing focal nodular hyperplasia (FNH) from hepatic adenoma (HA), the identification of early hepatocellular carcinoma (HCC) and the pre-operative assessment of metastasis in liver parenchyma. Regarding the differentiation between FNH and HA, adenoma typically appears hypointense in hepatobiliary phase, whereas FNH is isointense or hyperintense to the surrounding hepatic parenchyma. As for the identification of early HCCs, many papers recently published in literature have emphasized the contribution of hepatobiliary phase in the characterization of nodules without a typical hallmark of HCC. Atypical nodules (no hypervascularizaton observed on arterial phase and/or no hypovascular appearance on portal phase) with low signal intensity in the hepatobiliary phase, have a high probability of malignancy. Finally, regarding the evaluation of focal hepatic metastases, magnetic resonance pre-operative assessment using gadoxetic acid allows for more accurate diagnosis.
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