ReviewWorld journal of hepatology2014
Juvenile autoimmune hepatitis: Spectrum of the disease.
Review in World journal of hepatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06020976 (Pattern of Autoimmune Hepatitis in Children In Sohag University Hospital), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pattern of Autoimmune Hepatitis in Children In Sohag University Hospital
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- KASL clinical practice guidelines for management of autoimmune hepatitis 2022.Clinical and molecular hepatology · 2023Guideline
- Whole Exome Sequencing in Children With Autoimmune Hepatitis Identified Mutations in Genes Involved in the mTORC1 Signaling Pathway.Gastro hep advances · 2026Article
- Glucocorticoid receptors: The key of the response to steroid therapy in autoimmune hepatitis.Clinical and experimental hepatology · 2024Article
- Pediatric Autoimmune Hepatitis.Pediatric reports · 2024Article
- Juvenile Autoimmune Hepatitis: Recent Advances in Diagnosis, Management and Long-Term Outcome.Diagnostics (Basel, Switzerland) · 2023Review
- Seronegative autoimmune hepatitis in children : A real diagnostic challenge.Wiener klinische Wochenschrift · 2022Article
- Sarcopenia is highly prevalent in children with autoimmune liver diseases and is linked to visceral fat and parent-perceived general health.Liver international : official journal of the International Association for the Study of the Liver · 2022Article
- The association between juvenile autoimmune hepatitis and HLA-DRB1 alleles: Iraqi tertiary center experience.Clinical and experimental hepatology · 2021Article
- Prednisolone therapy for chronic hepatitis in English springer spaniels: a prospective study of 12 cases.The Veterinary record · 2020Article
- Clinical characteristics of paediatric autoimmune hepatitis at a referral hospital in Sub Saharan Africa.PloS one · 2020Article
- Hepatic expression of programmed death-1 (PD-1) and its ligand, PD-L1, in children with autoimmune hepatitis: relation to treatment response.Clinical and experimental hepatology · 2019Article
- Novel Diagnostic and Therapeutic Strategies in Juvenile Autoimmune Hepatitis.Frontiers in pediatrics · 2019Review
- Potential triggering factors of acute liver failure as a first manifestation of autoimmune hepatitis-a single center experience of 52 adult patients.World journal of gastroenterology · 2018Article
- Severe transaminitis in a paediatric patient with systemic lupus erythaematosus and a discussion of the literature.BMJ case reports · 2016Article
- Autoimmune hepatitis in Egyptian children: A single center experience.International journal of immunopathology and pharmacologyObservational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Juvenile autoimmune hepatitis (JAIH) is a progressive inflammatory liver disease, affecting mainly young girls, from infancy to late adolescence, characterized by active liver damage, as shown by high serum activity of aminotransferases, by elevated immunoglobulin G levels, high titers of serum non organ-specific and organ-specific autoantibodies, and by interface hepatitis on liver biopsy. It is a multifactorial disease of unknown etiology in which environmental factors act as a trigger in genetically predisposed individuals. Two types of JAIH are identified according to the autoantibody panel detected at diagnosis: AIH-1, characterized by the presence of anti-smooth muscle antibody and/or antinuclear antibody and AIH-2, by anti-liver-kidney microsomal antibody type 1 and/or by the presence of anti-liver cytosol type 1 antibody. Epidemiological distribution, genetic markers, clinical presentation and pattern of serum cytokines differentiate the two types of AIH suggesting possible pathogenetic mechanisms. The most effective therapy for AIH is pharmacological suppression of the immune response. Treatment should be started as soon as the diagnosis is made to avoid severe liver damage and progression of fibrosis. The aim of this review is to outline the most significant and peculiar features of JAIH, based largely on our own personal database and on a review of current literature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.