ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2014
Mild cold-stress depresses immune responses: Implications for cancer models involving laboratory mice.
Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
- Cardio-Oncology in Cold Climates: Epidemiological Features, Bidirectional Interaction Mechanisms, and Integrated Management Strategies.Cardiovascular toxicology · 2026Review
- Ethological Constraints and Welfare-Related Bias in Laboratory Mice: Implications of Housing, Lighting, and Social Environment.Animals : an open access journal from MDPI · 2026Review
- Integrated miRNA-mRNA Atlas Reveals Temperature-Graded Brain Neuroendocrine Adaptation to Cold Stress in Silvery Pomfret (Biology · 2025Article
- Article
- Characteristics of the Gut Microbiota Composition of the Arctic Zone Residents in the Far Eastern Region.Biomedicines · 2024Article
- Association between Environmental Temperature and Survival in Gastroesophageal Cancers: A Population Based Study.Cancers · 2023Article
- Consideration of the importance of measuring thermal discomfort in biomedical research.Trends in molecular medicine · 2023Review
- RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure.Cell stress & chaperones · 2022Article
- 'Invisible actors'-How poor methodology reporting compromises mouse models of oncology: A cross-sectional survey.PloS one · 2022Article
- Mild cold stress specifically disturbs clustering movement of DFCs and sequential organ left-right patterning in zebrafish.Frontiers in cell and developmental biology · 2022Article
- Effect of Different Pig Fecal Microbiota Transplantation on Mice Intestinal Function and Microbiota Changes During Cold Exposure.Frontiers in veterinary science · 2022Article
- Depth of tumor implantation affects response to in situ vaccination in a syngeneic murine melanoma model.Journal for immunotherapy of cancer · 2021Article
- Thermoneutral Housing Temperature Improves Survival in a Murine Model of Polymicrobial Peritonitis.Shock (Augusta, Ga.) · 2020Article
- Focal dynamic thermal imaging for label-free high-resolution characterization of materials and tissue heterogeneity.Scientific reports · 2020Article
- Thermoneutrality and Immunity: How Does Cold Stress Affect Disease?Frontiers in immunology · 2020Review
- Manipulation of Ambient Housing Temperature To Study the Impact of Chronic Stress on Immunity and Cancer in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2019Review
- Immune Relevant and Immune Deficient Mice: Options and Opportunities in Translational Research.ILAR journal · 2018Review
- Effects of Rodent Thermoregulation on Animal Models in the Research Environment.Comparative medicine · 2018Review
- The Comparative Biology of Mitochondrial Function and the Rate of Aging.Integrative and comparative biology · 2018Article
- BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes.Mucosal immunology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Physiologically accurate mouse models of cancer are critical in the pre-clinical development of novel cancer therapies. However, current standardized animal-housing temperatures elicit chronic cold-associated stress in mice, which is further increased in the presence of tumor. This cold-stress significantly impacts experimental outcomes. Data from our lab and others suggest standard housing fundamentally alters murine physiology, and this can produce altered immune baselines in tumor and other disease models. Researchers may thus underestimate the efficacy of therapies that are benefitted by immune responses. A potential mediator, norepinephrine, also underlies stress pathways common in mice and humans. Therefore, research into mechanisms connecting cold-stress and norepinephrine signaling with immune depression in mice could highlight new combination therapies for humans to simultaneously target stress while stimulating anti-tumor immunity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.