ArticleThe Journal of urology2015
Bladder reinnervation using a primarily motor donor nerve (femoral nerve branches) is functionally superior to using a primarily sensory donor nerve (genitofemoral nerve).
Article in The Journal of urology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Article
- Nerve transfer for restoration of lower motor neuron-lesioned bladder, urethral and anal sphincter function. Part 4: Effectiveness of the motor reinnervation.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Anatomical Location of the Vesical Branches of the Inferior Hypogastric Plexus in Human Cadavers.Diagnostics (Basel, Switzerland) · 2024Article
- Nerve transfer for restoration of lower motor neuron-lesioned bladder, urethral, and anal sphincter function in a dog model. Part 3. nicotinic receptor characterization.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Restoring bladder function using motor and sensory nerve transfers: a cadaveric feasibility study.Journal of neurosurgery. Spine · 2023Article
- Lateralization of bladder function in normal female canines.PloS one · 2022Article
- Nerve transfer for restoration of lower motor neuron-lesioned bladder function. Part 2: correlation between histological changes and nerve evoked contractions.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Nerve transfer for restoration of lower motor neuron-lesioned bladder function. Part 1: attenuation of purinergic bladder smooth muscle contractions.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Anatomical feasibility of peripheral nerve transfer to reestablish external anal sphincter control - cadaveric study.Surgical and radiologic anatomy : SRA · 2021Article
- Nerve transfer for restoration of lower motor neuron-lesioned bladder and urethra function: establishment of a canine model and interim pilot study results.Journal of neurosurgery. Spine · 2020Article
- Bladder and Bowel Management in Dogs With Spinal Cord Injury.Frontiers in veterinary science · 2020Review
- Bladder reinnervation by somatic nerve transfer to pelvic nerve vesical branches does not reinnervate the urethra.Neurourology and urodynamics · 2020Article
- Ipsilateral S2 nerve root transfer to pudendal nerve for restoration of external anal and urethral sphincter function: an anatomical study.Scientific reports · 2019Article
- Article
- Determining integrity of bladder innervation and smooth muscle function 1 year after lower spinal root transection in canines.Neurourology and urodynamics · 2018Article
- Clarification of the Innervation of the Bladder, External Urethral Sphincter and Clitoris: A Neuronal Tracing Study in Female Mongrel Hound Dogs.Anatomical record (Hoboken, N.J. : 2007) · 2018Article
- Evidence of vagus nerve sprouting to innervate the urinary bladder and clitoris in a canine model of lower motoneuron lesioned bladder.Neurourology and urodynamics · 2017Article
- Neuromuscular nicotinic receptors mediate bladder contractions following bladder reinnervation with somatic to autonomic nerve transfer after decentralization by spinal root transection.The Journal of urology · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeWe determined whether transfer of a primarily motor nerve (femoral) to the anterior vesicle branch of the pelvic nerve would allow for more effective bladder reinnervation than transfer of a primarily sensory nerve (genitofemoral). MATERIALS AND
methodsA total of 41 female mongrel dogs underwent bladder decentralization and then bilateral nerve transfer, or served as sham operated or unoperated controls. Decentralization was achieved by bilateral transection of all sacral roots that induced bladder contraction upon electrical stimulation. Retrograde neuronal labeling dye was injected in the bladder 3 weeks before sacrifice.
resultsIncreased detrusor pressure after direct stimulation of the transferred nerve, lumbar spinal cord or spinal root was observed in 12 of 17 dogs with genitofemoral nerve transfer and in 9 of 10 with femoral nerve transfer (mean ± SEM 7.6 ± 1.4 and 11.7 ± 3.1 cm H2O, respectively). Mean detrusor pressure after direct electrical stimulation of transferred femoral nerves was statistically significantly greater than after stimulation of transferred genitofemoral nerves. Retrograde labeled neurons from the bladder observed in upper lumbar cord segments after genitofemoral and femoral nerve transfer confirmed bladder reinnervation, as did labeled axons at the nerve transfer site.
conclusionsWhile transfer of a mixed sensory and motor nerve (genitofemoral) or a primarily motor nerve (femoral) can reinnervate the bladder, using the primarily motor nerve provided greater return of nerve evoked detrusor contraction. This surgical approach may be useful to achieve bladder emptying in patients with lower motor spinal cord injury.
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