ArticlePsychological medicine2015
Processing speed impairment in schizophrenia is mediated by white matter integrity.
Article in Psychological medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Processing Speed Impairment in Schizophrenia: An Updated Systematic Review and Meta-Analysis.JAMA psychiatry · 2026Pooled it
- Neurofilament Light Protein as a Biomarker in Severe Mental Disorders: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- N-Acetyl-Cysteine Supplementation Improves Functional Connectivity Within the Cingulate Cortex in Early Psychosis: A Pilot Study.The international journal of neuropsychopharmacology · 2019Trial
- Neuroinflammation and white matter microstructure as mediators of cognitive deficits in offspring of parents with bipolar disorder.Brain communications · 2026Article
- Cerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum.Frontiers in psychiatry · 2025Article
- Reduced finger tapping speed in patients with schizophrenia and psychomotor slowing: an exploratory fMRI study.Frontiers in psychiatry · 2025Article
- Electrophysiological recording during touchscreen-based behavioral assays in rodents: A platform for improving early-stage neuroscience drug discovery.Journal of neurochemistry · 2025Review
- Accelerating Heritability, Genetic Correlation, and Genome-Wide Association Imaging Genetic Analyses in Complex Pedigrees.Human brain mapping · 2024Article
- Adaptive coding of reward in schizophrenia, its change over time and relationship to apathy.Brain : a journal of neurology · 2024Article
- Negative symptoms and social cognition as mediators of the relationship between neurocognition and functional outcome in schizophrenia.Frontiers in psychiatry · 2024Article
- Neuroimaging features of cognitive impairments in schizophrenia and major depressive disorder.Therapeutic advances in psychopharmacology · 2024Review
- Antipsychotics-induced improvement of cool executive function in individuals living with schizophrenia.Frontiers in psychiatry · 2023Article
- Cognitive deficits, clinical variables, and white matter microstructure in schizophrenia: a multisite harmonization study.Molecular psychiatry · 2022Article
- Neurodevelopmental model of schizophrenia revisited: similarity in individual deviation and idiosyncrasy from the normative model of whole-brain white matter tracts and shared brain-cognition covariation with ADHD and ASD.Molecular psychiatry · 2022Article
- Single episode brief psychotic disorder versus bipolar disorder: A diffusion tensor imaging and executive functions study.Schizophrenia research. Cognition · 2022Review
- Functional Connectome Dynamics After Mild Traumatic Brain Injury According to Age and Sex.Frontiers in aging neuroscience · 2022Article
- Network analysis of cognitive deficit in patients with schizophrenia spectrum disorders.Schizophrenia research. Cognition · 2021Article
- The association between cytokines and psychomotor speed in a spectrum of psychotic disorders: A longitudinal study.Brain, behavior, & immunity - health · 2021Article
- Analysis of Diffusion Tensor Imaging Data From the UK Biobank Confirms Dosage Effect of 15q11.2 Copy Number Variation on White Matter and Shows Association With Cognition.Biological psychiatry · 2021Article
- Relationship of Corpus Callosum Integrity with Working Memory, Planning, and Speed of Processing in Patients with First-Episode and Chronic Schizophrenia.Journal of clinical medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundProcessing speed predicts functional outcome and is a potential endophenotype for schizophrenia. Establishing the neural basis of processing speed impairment may inform the treatment and etiology of schizophrenia. Neuroimaging investigations in healthy subjects have linked processing speed to brain anatomical connectivity. However, the relationship between processing speed impairment and white matter (WM) integrity in schizophrenia is unclear.
methodIndividuals with schizophrenia and healthy subjects underwent diffusion tensor imaging (DTI) and completed a brief neuropsychological assessment that included measures of processing speed, verbal learning, working memory and executive functioning. Group differences in WM integrity, inferred from fractional anisotropy (FA), were examined throughout the brain and the hypothesis that processing speed impairment in schizophrenia is mediated by diminished WM integrity was tested.
resultsWM integrity of the corpus callosum, cingulum, superior and inferior frontal gyri, and precuneus was reduced in schizophrenia. Average FA in these regions mediated group differences in processing speed but not in other cognitive domains. Diminished WM integrity in schizophrenia was accounted for, in large part, by individual differences in processing speed.
conclusionsCognitive impairment in schizophrenia was mediated by reduced WM integrity. This relationship was strongest for processing speed because deficits in working memory, verbal learning and executive functioning were not mediated by WM integrity. Larger sample sizes may be required to detect more subtle mediation effects in these domains. Interventions that preserve WM integrity or ameliorate WM disruption may enhance processing speed and functional outcome in schizophrenia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.