ArticleArtificial organs2015
The CentriMag centrifugal blood pump as a benchmark for in vitro testing of hemocompatibility in implantable ventricular assist devices.
Article in Artificial organs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Hemocompatibility of Mechanical Circulatory Support Devices: An Integrated Review of Platelet Function Assessment in In-Vitro Blood Experiments.Annals of biomedical engineering · 2026Pooled it
- Article
- In Vitro Hemocompatibility of the BiVACOR Total Artificial Heart in Continuous and Pulsatile Flow.Artificial organs · 2026Article
- Blood perfusion through ventricular assist devices induces erythrocytes to interact with leukocytes.Biochemistry and biophysics reports · 2025Article
- A comprehensive comparison of theFrontiers in physiology · 2023Article
- How to Optimize ECLS Results beyond Ventricular Unloading: From ECMO to CentriMagJournal of clinical medicine · 2022Article
- Extracorporeal Life Support and Temporary CentriMag Ventricular Assist Device to Salvage Cardiogenic-Shock Patients Suffering from Prolonged Cardiopulmonary Resuscitation.Journal of clinical medicine · 2022Article
- Flow characteristics and hemolytic performance of the new Breethe centrifugal blood pump in comparison with the CentriMag and Rotaflow pumps.The International journal of artificial organs · 2021Article
- Extracorporeal Membrane Oxygenation-Induced Hemolysis: An In Vitro Study to Appraise Causative Factors.Membranes · 2021Article
- Hemodynamic evaluation andAnnals of translational medicine · 2021Article
- Complications associated with mechanical circulatory support.Annals of translational medicine · 2020Review
- Temporary mechanical circulatory support for refractory heart failure: the German Heart Center Berlin experience.Annals of cardiothoracic surgery · 2019Article
- Extracellular vesicles: biomarkers and regulators of vascular function during extracorporeal circulation.Oncotarget · 2018Review
- Flow-induced platelet activation in components of the extracorporeal membrane oxygenation circuit.Scientific reports · 2018Article
- Plasma Free Hemoglobin Generation Using the EOS PMPThe journal of extra-corporeal technology · 2018Article
- Flow features and device-induced blood trauma in CF-VADs under a pulsatile blood flow condition: A CFD comparative study.International journal for numerical methods in biomedical engineering · 2018Article
- The Inflammatory Response to Ventricular Assist Devices.Frontiers in immunology · 2018Review
- Artificial hearts-recent progress: republication of the article published in the Japanese Journal of Artificial Organs.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Implantable ventricular assist devices (VADs) have proven efficient in advanced heart failure patients as a bridge-to-transplant or destination therapy. However, VAD usage often leads to infection, bleeding, and thrombosis, side effects attributable to the damage to blood cells and plasma proteins. Measuring hemolysis alone does not provide sufficient information to understand total blood damage, and research exploring the impact of currently available pumps on a wider range of blood cell types and plasma proteins such as von Willebrand factor (vWF) is required to further our understanding of safer pump design. The extracorporeal CentriMag (Thoratec Corporation, Pleasanton, CA, USA) has a hemolysis profile within published standards of normalized index of hemolysis levels of less than 0.01 g/100 L at 100 mm Hg but the effect on leukocytes, vWF multimers, and platelets is unknown. Here, the CentriMag was tested using bovine blood (n = 15) under constant hemodynamic conditions in comparison with a static control for total blood cell counts, hemolysis, leukocyte death, vWF multimers, microparticles, platelet activation, and apoptosis. The CentriMag decreased the levels of healthy leukocytes (P < 0.006), induced leukocyte microparticles (P < 10(-5) ), and the level of high molecular weight of vWF multimers was significantly reduced in the CentriMag (P < 10(-5) ) all compared with the static treatment after 6 h in vitro testing. Despite the leukocyte damage, microparticle formation, and cleavage of vWF multimers, these results show that the CentriMag is a hemocompatible pump which could be used as a standard in blood damage assays to inform the design of new implantable blood pumps.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.