Trial reportBMC geriatrics2014
The descriptive epidemiology of delirium symptoms in a large population-based cohort study: results from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).
Trial report in BMC geriatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Reporting of outcomes and measures in studies of interventions to prevent and/or treat delirium in older adults resident in long-term care: a systematic review.Age and ageing · 2022Pooled it
- J-shaped relationship between stress hyperglycemia ratio and delirium risk in critically ill patients: A population-based study.PloS one · 2026Article
- Delirium in the long-term care: a challenge for clinicians and researchers-the negative outcomes related to delirium: a scoping review.European geriatric medicine · 2025Article
- The Relationship between Delirium and Dementia.Seminars in neurology · 2024Review
- Delirium is more common and associated with worse outcomes in Parkinson's disease compared to older adult controls: results of two prospective longitudinal cohort studies.Age and ageing · 2024Article
- Heart rate response and recovery during exercise predict future delirium risk-A prospective cohort study in middle- to older-aged adults.Journal of sport and health science · 2023Article
- Association of Poor Sleep Burden in Middle Age and Older Adults With Risk for Delirium During Hospitalization.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Urinary Tract Infection in Parkinson's Disease.Journal of Parkinson's disease · 2022Review
- Hospitalisation without delirium is not associated with cognitive decline in a population-based sample of older people-results from a nested, longitudinal cohort study.Age and ageing · 2021Article
- Recurrent delirium over 12 months predicts dementia: results of the Delirium and Cognitive Impact in Dementia (DECIDE) study.Age and ageing · 2021Article
- Anticholinergic Burden Does Not Influence Delirium Subtype or the Delirium-Mortality Association in Hospitalized Older Adults: Results from a Prospective Cohort Study.Drugs & aging · 2021Article
- Impaired Executive Function and Depression as Independent Risk Factors for Reported Delirium Symptoms: An Observational Cohort Study Over 8 Years.Frontiers in aging neuroscience · 2021Article
- Delirium Post-Stroke-Influence on Post-Stroke Dementia (Research Study-Part of the PROPOLIS Study).Journal of clinical medicine · 2020Article
- Delirium in Internal Medicine Departments in a Tertiary Hospital in Israel: Occurrence, Detection Rates, Risk Factors, and Outcomes.Frontiers in medicine · 2020Article
- An interdisciplinary statement of scientific societies for the advancement of delirium care across Europe (EDA, EANS, EUGMS, COTEC, IPTOP/WCPT).BMC geriatrics · 2019Article
- Association of Duration of Surgery With Postoperative Delirium Among Patients Receiving Hip Fracture Repair.JAMA network open · 2019Article
- Delirium symptoms are associated with decline in cognitive function between ages 53 and 69 years: Findings from a British birth cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Article
- The delirium and population health informatics cohort study protocol: ascertaining the determinants and outcomes from delirium in a whole population.BMC geriatrics · 2018Observational
- Using quality assessment tools to critically appraise ageing research: a guide for clinicians.Age and ageing · 2017Review
- Protocol for the Delirium and Cognitive Impact in Dementia (DECIDE) study: A nested prospective longitudinal cohort study.BMC geriatrics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundIn the general population, the epidemiological relationships between delirium and adverse outcomes are not well defined. The aims of this study were to: (1) construct an algorithm for the diagnosis of delirium using the Geriatric Mental State (GMS) examination; (2) test the criterion validity of this algorithm against mortality and dementia risk; (3) report the age-specific prevalence of delirium as determined by this algorithm.
methodsParticipant and informant data in a randomly weighted subsample of the Cognitive Function and Ageing Study were taken from a standardized assessment battery. The algorithmic definition of delirium was based on the DSM-IV classification. Outcomes were: proportional hazard ratios for death; odds ratios of dementia at 2-year follow-up.
resultsData from 2197 persons (representative of 13,004) were used, median age 77 years, 64% women. Study-defined delirium was associated with a new dementia diagnosis at two years (OR 8.82, 95% CI 2.76 to 28.2) and death (HR 1.28, 95% CI 1.03 to 1.60), even after adjustment for acute illness severity. Similar associations were seen for study-defined subsyndromal delirium. Age-specific prevalence as determined by the algorithm increased with age from 1.8% in the 65-69 year age group to 10.1% in the ≥85 age group (p < 0.01 for trend). For study-defined subsyndromal delirium, age-specific period prevalence ranged from 8.2% (65-69 years) to 36.1% (≥85 years).
conclusionsThese results demonstrate the possibility of constructing an algorithmic diagnosis for study-defined delirium using data from the GMS schedule, with predictive criterion validity for mortality and dementia risk. These are the first population-based analyses able to account prospectively for both illness severity and an earlier study diagnosis of dementia.
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