Evidence map›Paper›PMID 25066485›Full record

ArticleHormones and behavior2014

Temperament moderates the influence of periadolescent social experience on behavior and adrenocortical activity in adult male rats.

M J Caruso, M K McClintock, S A Cavigelli

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hormones and behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

M J CarusoDepartment of Biobehavioral Health, Pennsylvania State University, University Park, PA 16802, USA; Center for Brain, Behavior, and Cognition, Pennsylvania State University, University Park, PA 16802, USA. Electronic address: mjc5038@psu.edu.
M K McClintockDepartment of Psychology, University of Chicago, Chicago, IL 60637, USA; The Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, USA. Electronic address: mkm1@uchicago.edu.
S A CavigelliDepartment of Biobehavioral Health, Pennsylvania State University, University Park, PA 16802, USA; Center for Brain, Behavior, and Cognition, Pennsylvania State University, University Park, PA 16802, USA; The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA. Electronic address: sac34@psu.edu.
Pennsylvania State University · USUniversity of Chicago · US

Funding

THE SOCIAL ENVIRONMENT, LONELINESS, STRESS AND HEALTHP01AG018911 · NIA · UNIVERSITY OF CHICAGO · PI CACIOPPO, JOHN T. · 2001 to 2007
$8.0M
PHEROMONES, BEHAVIOR AND THE REGULATION OF FERTILITYR37MH041788 · NIMH · UNIVERSITY OF CHICAGO · PI MCCLINTOCK, MARTHA K · 1992 to 2001
$543k
Peri-pubertal Adrenal and Immune Function DevelopmentF32HD008693 · NICHD · UNIVERSITY OF CHICAGO · PI CAVIGELLI, SONIA A · 2001 to 2003
$135k
NIA NIH HHS P01 AG018911NICHD NIH HHS F32 HD008693NICHD NIH HHS F32 HD08693NIMH NIH HHS R37 MH041788NIMH NIH HHS R37 MH41788
6 · The paper itself

Abstract

Adolescence is a period of significant behavioral and physiological maturation, particularly related to stress responses. Animal studies that have tested the influence of adolescent social experiences on stress-related behavioral and physiological development have led to complex results. We used a rodent model of neophobia to test the hypothesis that the influence of adolescent social experience on adult behavior and adrenocortical function is modulated by pre-adolescent temperament. Exploratory activity was assessed in 53 male Sprague-Dawley rats to classify temperament and then they were housed in one of the three conditions during postnatal days (PND) 28-46: (1) with familiar kin, (2) with novel social partners, or (3) individually with no social partners. Effects on adult adrenocortical function were evaluated from fecal samples collected while rats were individually-housed and exposed to a 1-hour novel social challenge during PND 110-114. Adolescent-housing with novel or no social partners led to reduced adult glucocorticoid production compared to adolescent-housing with familiar littermates. Additionally, highly-exploratory pre-weanling rats that were housed with novel social partners during adolescence exhibited increased exploratory behavior and a more rapid return to basal glucocorticoid production in adulthood compared to those housed with familiar or no social partners during adolescence and compared to low-exploratory rats exposed to novel social partners. In sum, relatively short-term adolescent social experiences can cause transient changes in temperament and potentially longer-term changes in recovery of glucocorticoid production in response to adult social challenges. Furthermore, early temperament may modulate the influence of adolescent experiences on adult behavioral and adrenocortical function.

Indexed as

Social BehaviorAdrenal CortexAge FactorsAnimalsBehavior, AnimalExploratory BehaviorGlucocorticoidsMaleRatsRats, Sprague-DawleySexual MaturationTemperamentGlucocorticoidsAdolescenceBehavioral inhibitionFecal corticoidNeophobiaSocial experience

Identifiers

PMID25066485
PMCPMC4498393
OpenAlexW2069170519

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.