ArticlePsychological medicine2015
Gene-environment interplay between parent-child relationship problems and externalizing disorders in adolescence and young adulthood.
Article in Psychological medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Behavioral Disinhibition Model of Addiction: A Review and New Findings from the Minnesota Twin Family Study.Behavior genetics · 2026Review
- Gene-Environment Interplay Beyond Interactions: Psychosocial Environments Mediate Genetic Effects Underlying Externalizing-Behavior Trajectories.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Article
- Lability in parent-child warmth and hostility and adolescent externalizing behaviors.Developmental psychology · 2025Article
- Polygenic risk and childhood adversity as moderators of drug and alcohol withdrawal symptoms.Drug and alcohol dependence · 2025Article
- Research Review: A review of the past decade of family and genomic studies on adolescent mental health.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- The Heritability of Psychopathology Symptoms in Early Adolescence: Moderation by Family Cultural Values in the ABCD Study.Behavior genetics · 2024Article
- Developmental profiles of child behavior problems from 18 months to 8 years: The protective effects of structured parenting vary by genetic risk.Development and psychopathology · 2022Article
- The Associations of Polygenic Scores for Risky Behaviors and Parenting Behaviors with Adolescent Externalizing Problems.Behavior genetics · 2022Article
- Internet Addiction: The Role of Parental Care and Mental Health in Adolescence.International journal of environmental research and public health · 2021Article
- Mapping Pathways by Which Genetic Risk Influences Adolescent Externalizing Behavior: The Interplay Between Externalizing Polygenic Risk Scores, Parental Knowledge, and Peer Substance Use.Behavior genetics · 2021Article
- Personality, romantic relationships, and alcohol use disorder symptoms in adolescence and young adulthood: An evaluation of personality × social context interplay.Development and psychopathology · 2020Article
- Parenting, Effortful Control, and Adolescents' Externalizing Problem Behavior: Moderation by Dopaminergic Genes.Journal of youth and adolescence · 2020Article
- Online activities, prevalence of Internet addiction and risk factors related to family and school among adolescents in China.Addictive behaviors reports · 2018Article
- The Developmental Unfolding of Sibling Influences on Alcohol Use over Time.Journal of youth and adolescence · 2018Article
- Antisocial peer affiliation and externalizing disorders: Evidence for Gene × Environment × Development interaction.Development and psychopathology · 2017Article
- A Test-Replicate Approach to Candidate Gene Research on Addiction and Externalizing Disorders: A Collaboration Across Five Longitudinal Studies.Behavior genetics · 2016Article
- Genetic Influences on Peer and Family Relationships Across Adolescent Development: Introduction to the Special Issue.Journal of youth and adolescence · 2015Article
- Environment-by-PGS Interaction in the Classical Twin Design: An Application to Childhood Anxiety and Negative Affect.Multivariate behavioral researchArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPrevious studies have shown that genetic risk for externalizing (EXT) disorders is greater in the context of adverse family environments during adolescence, but it is unclear whether these effects are long lasting. The current study evaluated developmental changes in gene-environment interplay in the concurrent and prospective associations between parent-child relationship problems and EXT at ages 18 and 25 years.
methodThe sample included 1382 twin pairs (48% male) from the Minnesota Twin Family Study, participating in assessments at ages 18 years (mean = 17.8, s.d. = 0.69 years) and 25 years (mean = 25.0, s.d. = 0.90 years). Perceptions of parent-child relationship problems were assessed using questionnaires. Structured interviews were used to assess symptoms of adult antisocial behavior and nicotine, alcohol and illicit drug dependence.
resultsWe detected a gene-environment interaction at age 18 years, such that the genetic influence on EXT was greater in the context of more parent-child relationship problems. This moderation effect was not present at age 25 years, nor did parent-relationship problems at age 18 years moderate genetic influence on EXT at age 25 years. Rather, common genetic influences accounted for this longitudinal association.
conclusionsGene-environment interaction evident in the relationship between adolescent parent-child relationship problems and EXT is both proximal and developmentally limited. Common genetic influence, rather than a gene-environment interaction, accounts for the long-term association between parent-child relationship problems at age 18 years and EXT at age 25 years. These results are consistent with a relatively pervasive importance of gene-environmental correlation in the transition from late adolescence to young adulthood.
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