ArticleEuropean journal of clinical pharmacology2014
Ascertainment of acute liver injury in two European primary care databases.
Article in European journal of clinical pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Drug induced liver injury is associated with high mortality-A study from a tertiary care hospital in Pakistan.PloS one · 2020Article
- Differences between diabetic and non-diabetic patients with community-acquired pneumonia in primary care in Spain.BMC infectious diseases · 2019Article
- Incidence of direct oral anticoagulant use in patients with nonvalvular atrial fibrillation and characteristics of users in 6 European countries (2008-2015): A cross-national drug utilization study.British journal of clinical pharmacology · 2019Article
- Article
- Antidepressant-Induced Acute Liver Injury: A Case-Control Study in an Italian Inpatient Population.Drug safety · 2018Article
- Validation and incidence of community-acquired pneumonia in patients with type 2 diabetes in the BIFAP database.Epidemiology and infection · 2017Article
- Use of oral antidiabetic agents and risk of community-acquired pneumonia: a nested case-control study.British journal of clinical pharmacology · 2017Article
- Antibiotic-Induced Liver Injury in Paediatric Outpatients: A Case-Control Study in Primary Care Databases.Drug safety · 2017Article
- Epidemiology and Genetic Risk Factors of Drug Hepatotoxicity.Clinics in liver disease · 2017Review
- Incidence and risk factor prevalence of community-acquired pneumonia in adults in primary care in Spain (NEUMO-ES-RISK project).BMC infectious diseases · 2016Article
- Optimising case detection within UK electronic health records: use of multiple linked databases for detecting liver injury.BMJ open · 2016Article
- The risk of acute liver injury among users of antibiotic medications: a comparison of case-only studies.Pharmacoepidemiology and drug safety · 2016Article
- Review
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14 authors.
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Abstract
purposeThe purpose of this study was to ascertain acute liver injury (ALI) in primary care databases using different computer algorithms. The aim of this investigation was to study and compare the incidence of ALI in different primary care databases and using different definitions of ALI.
methodsThe Clinical Practice Research Datalink (CPRD) in UK and the Spanish "Base de datos para la Investigación Farmacoepidemiológica en Atención Primaria" (BIFAP) were used. Both are primary care databases from which we selected individuals of all ages registered between January 2004 and December 2009. We developed two case definitions of idiopathic ALI using computer algorithms: (i) restrictive definition (definite cases) and (ii) broad definition (definite and probable cases). Patients presenting prior liver conditions were excluded. Manual review of potential cases was performed to confirm diagnosis, in a sample in CPRD (21%) and all potential cases in BIFAP. Incidence rates of ALI by age, sex and calendar year were calculated.
resultsIn BIFAP, all cases considered definite after manual review had been detected with the computer algorithm as potential cases, and none came from the non-cases group. The restrictive definition of ALI had a low sensitivity but a very high specificity (95% in BIFAP) and showed higher rates of agreement between computer search and manual review compared to the broad definition. Higher incidence rates of definite ALI in 2008 were observed in BIFAP (3.01 (95% confidence interval (CI) 2.13-4.25) per 100,000 person-years than CPRD (1.35 (95% CI 1.03-1.78)).
conclusionsThis study shows that it is feasible to identify ALI cases if restrictive selection criteria are used and the possibility to review additional information to rule out differential diagnoses. Our results confirm that idiopathic ALI is a very rare disease in the general population. Finally, the construction of a standard definition with predefined criteria facilitates the timely comparison across databases.
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