Evidence map›Paper›PMID 25066366›Full record

Trial reportPsychological medicine2014

Age at onset, course of illness and response to psychotherapy in bipolar disorder: results from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD).

A Peters, L G Sylvia, P V da Silva Magalhães, D J Miklowitz, E Frank, M W Otto, N S Hansen, D D Dougherty, M Berk, A A Nierenberg and 1 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychological medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Collaborative care approaches for people with severe mental illness.The Cochrane database of systematic reviews · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

A PetersUniversity of Illinois at Chicago,Chicago, IL,USA.
L G SylviaMassachusetts General Hospital,Boston, MA,USA.
P V da Silva MagalhãesUniversidade Federal de Rio Grande de Sul,Porte Alegre,Brazil.
D J MiklowitzUCLA School of Medicine,Los Angeles, CA,USA.
E FrankUniversity of Pittsburgh,Pittsburgh, PA,USA.
M W OttoBoston University,Boston, MA,USA.
N S HansenMassachusetts General Hospital,Boston, MA,USA.
D D DoughertyMassachusetts General Hospital,Boston, MA,USA.
M BerkDeakin University,Melbourne,Australia.
A A NierenbergMassachusetts General Hospital,Boston, MA,USA.
T DeckersbachMassachusetts General Hospital,Boston, MA,USA.
Harvard University · USMassachusetts General Hospital · USDeakin University · AUUniversidade Federal do Rio Grande · BRUniversity of California, Los Angeles · USUniversity of Illinois Chicago · USUniversity of Pittsburgh · US

Funding

TREATMENT OF BIPOLAR DISORDER-278980001N01MH080001 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · 1998 to 2003
$5.3M
1/2-Early Intervention for Youth at Risk for Bipolar DisorderR01MH093676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2016
$3.6M
MAINTENANCE THERAPIES IN BIPOLAR DISORDERSR37MH029618 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FRANK, ELLEN · 1992 to 2002
$3.2M
Family-Focused Therapy for Youth with Early-Onset Bipolar or Psychotic Disorders R33MH097007 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2014 to 2016
$853k
Family-Focused Treatment for Youth with Early-Onset Bipolar or Psychotic DisorderR21MH097007 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2013
$439k
Medical Comorbidity, Medical Burden and Biopolar DisorderR01MH029618 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KUPFER, DAVID J · 1985 to 2006
$262k
INTEGRATED FAMILY/INDIVIDUAL THERAPY OF BIPOLAR DISORDERR21MH055101 · NIMH · UNIVERSITY OF COLORADO AT BOULDER · PI MIKLOWITZ, DAVID JAY · 1996 to 1998
–
FAMILY FACTORS AND OUTCOME IN BIPOLAR DISORDERR29MH043931 · NIMH · UNIVERSITY OF COLORADO AT BOULDER · PI MIKLOWITZ, DAVID JAY · 1991 to 1995
–
NIMH NIH HHS MH296181NIMH NIH HHS MH43931NIMH NIH HHS MH55101NIMH NIH HHS N01 MH080001NIMH NIH HHS R01 MH029618NIMH NIH HHS R01 MH093676NIMH NIH HHS R21 MH097007NIMH NIH HHS R33 MH097007NIMH NIH HHS R37 MH029618
6 · The paper itself

Abstract

backgroundThe course of bipolar disorder progressively worsens in some patients. Although responses to pharmacotherapy appear to diminish with greater chronicity, less is known about whether patients' prior courses of illness are related to responses to psychotherapy.

methodEmbedded in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) was a randomized controlled trial of psychotherapy for bipolar depression comparing the efficacy of intensive psychotherapy with collaborative care (a three-session psycho-educational intervention). We assessed whether the number of previous mood episodes, age of illness onset, and illness duration predicted or moderated the likelihood of recovery and time until recovery from a depressive episode in patients in the two treatments.

resultsIndependently of treatment condition, participants with one to nine prior depressive episodes were more likely to recover and had faster time to recovery than those with 20 or more prior depressive episodes. Participants with fewer than 20 prior manic episodes had faster time to recovery than those with 20 or more episodes. Longer illness duration predicted a longer time to recovery. Participants were more likely to recover in intensive psychotherapy than collaborative care if they had 10-20 prior episodes of depression [number needed to treat (NNT) = 2.0], but equally likely to respond to psychotherapy and collaborative care if they had one to nine (NNT = 32.0) or >20 (NNT = 9.0) depressive episodes.

conclusionsNumber of previous mood episodes and illness duration are associated with the likelihood and speed of recovery among bipolar patients receiving psychosocial treatments for depression.

Indexed as

AdolescentAdultAge of OnsetBipolar DisorderFemaleHumansMaleProgram EvaluationPsychiatric Status Rating ScalesPsychotherapyTime FactorsTreatment OutcomeUnited StatesYoung Adult

Identifiers

PMID25066366
PMCPMC4620042
OpenAlexW2167554978

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.