Evidence map›Paper›PMID 25066302›Full record

ArticleMolecular genetics and metabolism2014

Enhanced brain distribution of modified aspartoacylase.

Nitesh K Poddar, Stephen Zano, Reka Natarajan, Bryan Yamamoto, Ronald E Viola

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nitesh K PoddarDepartment of Chemistry and Biochemistry, University of Toledo, Toledo, OH 43606, USA.
Stephen ZanoDepartment of Chemistry and Biochemistry, University of Toledo, Toledo, OH 43606, USA.
Reka NatarajanDepartment of Neurosciences, University of Toledo, Toledo, OH 43614, USA.
Bryan YamamotoDepartment of Neurosciences, University of Toledo, Toledo, OH 43614, USA.
Ronald E ViolaDepartment of Chemistry and Biochemistry, University of Toledo, Toledo, OH 43606, USA. Electronic address: ron.viola@utoledo.edu.
University of Toledo · US

Funding

METHAMPHETAMINE TOXICITY AND CORTICOSTRIATAL GLUTAMATER01DA007606 · NIDA · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI YAMAMOTO, BRYAN K · 1992 to 2016
$5.1M
Methamphetamine, Stress and Brain EndotheliumR01DA035499 · NIDA · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI YAMAMOTO, BRYAN K · 2013 to 2017
$2.2M
NIDA NIH HHS DA007606NIDA NIH HHS R01 DA007606NIDA NIH HHS R01 DA035499
6 · The paper itself

Abstract

Canavan disease is a fatal neurological disorder caused by defects in the gene that produces the enzyme aspartoacylase. Enzyme replacement therapy can potentially be used to overcome these defects if a stable enzyme form that can gain access to the appropriate neural cells can be produced. Achieving the proper cellular targeting requires a modified form of aspartoacylase that can traverse the blood-brain barrier. A PEGylated form of aspartoacylase that shows dramatic enhancement in brain tissue access and distribution has been produced. While the mechanism of transport has not yet been established, this modified enzyme is significantly less immunogenic than unmodified aspartoacylase. These improved properties set the stage for more extensive enzyme replacement trials as a possible treatment strategy.

Indexed as

AmidohydrolasesAnimalsBlood-Brain BarrierBrainCanavan DiseaseDrug Evaluation, PreclinicalEnzyme Replacement TherapyHumansMalePolyethylene GlycolsRats, Sprague-DawleyTissue DistributionAmidohydrolasesaspartoacylasePolyethylene GlycolsAspartoacylaseBlood–brain barrierCanavan diseaseEnzyme replacement therapyPEGylation

Identifiers

PMID25066302
PMCPMC4252805
OpenAlexW2029612495

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.