ArticleMicrobiologyOpen2014
Outer membrane vesicles of Pasteurella multocida contain virulence factors.
Article in MicrobiologyOpen, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Outer Membrane Vesicles Derived from Yak Isolates ofAnimals : an open access journal from MDPI · 2026Article
- Advances inVaccines · 2025Review
- Characterization and immunological effect of outer membrane vesicles from Pasteurella multocida on macrophages.Applied microbiology and biotechnology · 2024Article
- Genomic and transcriptomics analysis reveal putative secreted proteins expressed ofFrontiers in veterinary science · 2024Article
- Article
- Role ofFrontiers in microbiology · 2023Review
- Outer Membrane Vesicles: An Emerging Vaccine Platform.Vaccines · 2022Review
- Transcriptomic Analysis of High- and Low-Virulence BovineFrontiers in veterinary science · 2021Article
- PamulDB: a comprehensive genomic resource for the study of human- and animal-pathogenic Pasteurella multocida.Database : the journal of biological databases and curation · 2019Article
- Development of a lateral flow test for the rapid detection of Avibacterium paragallinarum in chickens suspected of having infectious coryza.BMC veterinary research · 2018Article
- Bacterial outer membrane vesicles, a potential vaccine candidate in interactions with host cells based.Diagnostic pathology · 2018Review
- Genetic and Phylogenetic Characteristics ofFrontiers in microbiology · 2018Article
- The outer membrane phospholipase A is essential for membrane integrity and type III secretion in Shigella flexneri.Open biology · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pasteurella multocida (Pm) is a gram-negative bacterium able to infect different animal species, including human beings. This bacterium causes economic losses to the livestock industry because of its high morbidity and mortality in animals. In this work, we report the characterization of outer membrane vesicles (OMVs) released into the culture medium by different Pm serogroups. Purified OMVs in the range of 50-300 nm were observed by electron microscopy. Serum obtained from chickens infected with Pm recognized several proteins from Pm OMVs. Additionally, rabbit antiserum directed against a secreted protease from Actinobacillus pleuropneumoniae recognized a similar protein in the Pm OVMs, suggesting that OMVs from these bacterial species contain common immunogenic proteins. OmpA, a multifunctional protein, was identified in OMVs from different Pm serogroups, and its concentration was twofold higher in OMVs from Pm serogroups B and D than in OMVs from other serogroups. Three outer membrane proteins were also identified: OmpH, OmpW, and transferrin-binding protein. Three bands of 65, 110, and 250 kDa with proteolytic activity were detected in Pm OMVs of serogroups A and E. Additionally, β-lactamase activity was detected only in OMVs from Pm 12945 Amp(r) (serogroup A). Pm OMVs may be involved in different aspects of disease pathogenesis.
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Registered trials
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