Evidence map›Paper›PMID 25065890›Full record

ReviewMethods in enzymology2014

Noncanonical cell death in the nematode Caenorhabditis elegans.

Maxime J Kinet, Shai Shaham

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Methods in enzymology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Programmed cell death in aging.Ageing research reviews · 2015
    Review
  5. Microglia Function in Central Nervous System Development and Plasticity.Cold Spring Harbor perspectives in biology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Maxime J KinetLaboratory of Developmental Genetics, The Rockefeller University, New York, USA.
Shai ShahamLaboratory of Developmental Genetics, The Rockefeller University, New York, USA. Electronic address: shaham@rockefeller.edu.

Funding

Weill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1M
Control of nonapoptotic C. elegans cell death similar to neurodegenerationR01NS081490 · NINDS · ROCKEFELLER UNIVERSITY · PI SHAHAM, SHAI · 2012 to 2017
$2.2M
Control of Linker Cell Death in C. elegansR01HD078703 · NICHD · ROCKEFELLER UNIVERSITY · PI SHAHAM, SHAI · 2014 to 2018
$1.7M
NICHD NIH HHS HD078703NICHD NIH HHS R01 HD078703NIGMS NIH HHS T32 GM007739NIGMS NIH HHS T32GM07739NINDS NIH HHS NS081490NINDS NIH HHS R01 NS081490
6 · The paper itself

Abstract

The nematode Caenorhabditis elegans has served as a fruitful setting for cell death research for over three decades. A conserved pathway of four genes, egl-1/BH3-only, ced-9/Bcl-2, ced-4/Apaf-1, and ced-3/caspase, coordinates most developmental cell deaths in C. elegans. However, other cell death forms, programmed and pathological, have also been described in this animal. Some of these share morphological and/or molecular similarities with the canonical apoptotic pathway, while others do not. Indeed, recent studies suggest the existence of an entirely novel mode of programmed developmental cell destruction that may also be conserved beyond nematodes. Here, we review evidence for these noncanonical pathways. We propose that different cell death modalities can function as backup mechanisms for apoptosis, or as tailor-made programs that allow specific dying cells to be efficiently cleared from the animal.

Indexed as

AnimalsApoptosisCaenorhabditis elegansCaenorhabditis elegans ProteinsCalcium-Binding ProteinsCaspasesHumansNecrosisProto-Oncogene Proteins c-bcl-2Repressor ProteinsSignal TransductionCaenorhabditis elegans ProteinsCalcium-Binding ProteinsCaspasesced-3 protein, C elegansCed-4 protein, C elegansCed-9 protein, C elegansEGL-1 protein, C elegansProto-Oncogene Proteins c-bcl-2Repressor ProteinsApoptosisC. elegansCell deathLinkerMorphologyNecrosis

Identifiers

PMID25065890
PMCPMC4115798

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.