Evidence map›Paper›PMID 25065855›Full record

Trial reportBlood cells, molecules & diseases2014

A prospective randomized wait list control trial of intravenous iron sucrose in older adults with unexplained anemia and serum ferritin 20-200 ng/mL.

Elizabeth Price, Andrew S Artz, Huiman Barnhart, Shelly Sapp, Gordon Chelune, William B Ershler, Jeremy D Walston, Victor R Gordeuk, Nathan A Berger, David Reuben and 6 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Blood cells, molecules & diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Renal Toxicity Associated with Salsalate in Elderly Adults with Anemia.Journal of the American Geriatrics Society · 2016
    Trial
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 1 country.

Elizabeth PriceDivision of Pulmonary and Critical Care Medicine, 300 Pasteur Drive, Room H3143, MC 5236 Stanford, CA 94305, USA. Electronic address: eaprice@stanford.edu.
Andrew S ArtzUniversity of Chicago, 5841 S Maryland Ave., Chicago, IL 60637, USA. Electronic address: aartz@medicine.bsd.uchicago.edu.
Huiman BarnhartDuke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA. Electronic address: huiman.barnhart@duke.edu.
Shelly SappDuke University Medical Center, Durham, NC 27710, USA. Electronic address: shelly.sapp@duke.edu.
Gordon CheluneCenter for Alzheimer's Care, Imaging and Research, University of Utah, Dept. of Neurology, 650 Komas Drive, Salt Lake City, UT 84108, USA. Electronic address: gordon.chelune@hsc.utah.edu.
William B ErshlerInstitute for Advanced Studies in Aging, 6400 Arlington Blvd., Falls Church, VA 22042, USA. Electronic address: wershler@iasia.org.
Jeremy D WalstonJohns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA. Electronic address: jwalston@jhmi.edu.
Victor R GordeukUniversity of Illinois at Chicago, Clinical Science North Bldg., 820S Wood St., Chicago, IL 60612, USA. Electronic address: vgordeuk@uic.edu.
Nathan A BergerCase Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA. Electronic address: nab@case.edu.
David ReubenUniversity of California, Los Angeles Medical Center, 10945 Le Conte Ave., Los Angeles, CA 90095, USA. Electronic address: dreuben@mednet.ucla.edu.
Josef PrchalUniversity of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132, USA. Electronic address: josef.prchal@hsc.utah.edu.
Sunil V RaoDuke University Medical Center, Durham VA Medical Center, 508 Fulton Street, Durham, NC 27705, USA. Electronic address: sunil.rao@dm.duke.edu.
Cindy N RoyJohns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA. Electronic address: croy6@jhmi.edu.
Mark A SupianoUniversity of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132, USA. Electronic address: mark.supiano@utah.edu.
Stanley L SchrierStanford University, Stanford, CA 94305, USA. Electronic address: sschrier@stanford.edu.
Harvey Jay CohenDuke University Medical Center, Center for the Study of Aging, Box 3003, Durham, NC 27710, USA. Electronic address: harvey.cohen@dm.duke.edu.
Duke University · USUniversity of Utah · USJohns Hopkins University · USCase Western Reserve University · USPulmonary and Critical Care Associates · USStanford University · USUniversity of California, Los Angeles · USUniversity of Chicago · USUniversity of Illinois Chicago · US

Funding

Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
PACTTE-Partnership for Anemia: Clinical and Translational Trials in the ElderlyU01AG034661 · NIA · DUKE UNIVERSITY · PI COHEN, HARVEY JAY · 2009 to 2018
$14.7M
NCATS NIH HHS UL1 TR000430NIA NIH HHS 5U01AG034661NIA NIH HHS U01 AG034661
6 · The paper itself

Abstract

Anemia is common in older persons and is associated with substantial morbidity and mortality. One third of anemic older adults have unexplained anemia of the elderly (UAE). We carried out a randomized, wait list control trial in outpatients with UAE and serum ferritin levels between 20 and 200 ng/mL. Intravenous iron sucrose was given as a 200-mg weekly dose for 5 weeks either immediately after enrollment (immediate intervention group) or following a 12-week wait list period (wait list control group). The primary outcome measure was changed in 6-minute walk test (6MWT) distances from baseline to 12 weeks between the two groups. Hematologic, physical, cognitive, and quality of life parameters were also assessed. The study was terminated early after 19 subjects enrolled. The distance walked in the 6MWT increased a mean 8.05±55.48 m in the immediate intervention group and decreased a mean 11.45±49.46 m in the wait list control group (p=0.443). The hemoglobin increased a mean 0.39±0.46 g/dL in the immediate intervention group and declined a mean 0.39±0.85 g/dL in the wait list control group (p=0.026). Thus, a subgroup of adults with UAE may respond to intravenous iron. Enrollment of subjects into this type of study remains challenging.

Indexed as

AgedAged, 80 and overAnemiaCognitionDrug Administration ScheduleExercise TestFemaleFerric CompoundsFerric Oxide, SaccharatedFerritinsGlucaric AcidHumansInjections, IntravenousMalePsychological TestsQuality of LifeFerric CompoundsFerric Oxide, SaccharatedFerritinsGlucaric Acid6-Minute walk testHemoglobinIntravenous ironUnexplained anemia

Identifiers

PMID25065855
PMCPMC4198614
OpenAlexW2119538488

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.