ArticleOrganic & biomolecular chemistry2014
Orthogonal functionalisation of α-helix mimetics.
Article in Organic & biomolecular chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Tackling Undruggable Targets with Designer Peptidomimetics and Synthetic Biologics.Chemical reviews · 2024Review
- Aromatic Foldamer Helices as α-Helix Extended Surface Mimetics.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Rationally Designed Polypharmacology: α-Helix Mimetics as Dual Inhibitors of the Oncoproteins Mcl-1 and HDM2.ChemMedChem · 2020Article
- Article
- A catalytic protein-proteomimetic complex: using aromatic oligoamide foldamers as activators of RNase S.Chemical science · 2019Article
- Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein⁻Protein Interactions.Molecules (Basel, Switzerland) · 2018Review
- Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups.Organic & biomolecular chemistry · 2016Article
- Inhibition of the p53/hDM2 protein-protein interaction by cyclometallated iridium(III) compounds.Oncotarget · 2016Article
- Multi-Facial, Non-Peptidic α-Helix Mimetics.Biology · 2015Review
- Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.Angewandte Chemie (International ed. in English) · 2015Review
- Development of protein mimics for intracellular delivery.Biopolymers · 2015Review
- Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers.Chemical science · 2015Article
- Selective and potent proteomimetic inhibitors of intracellular protein-protein interactions.Angewandte Chemie (International ed. in English) · 2015Article
- Selective and Potent Proteomimetic Inhibitors of Intracellular Protein-Protein Interactions.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
α-Helix mediated protein-protein interactions are of major therapeutic importance. As such, the design of inhibitors of this class of interaction is of significant interest. We present methodology to modify N-alkylated aromatic oligoamide α-helix mimetics using 'click' chemistry. The effect is shown to modulate the binding properties of a series of selective p53/hDM2 inhibitors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.