Evidence map›Paper›PMID 25065728›Full record

ArticleJournal of biomechanics2014

Bioinjection treatment: effects of post-injection residual stress on left ventricular wall stress.

Lik Chuan Lee, Samuel T Wall, Martin Genet, Andy Hinson, Julius M Guccione

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomechanics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. A Contemporary Look at Biomechanical Models of Myocardium.Annual review of biomedical engineering · 2019
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Computational modeling of acute myocardial infarction.Computer methods in biomechanics and biomedical engineering · 2016
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Lik Chuan LeeDepartment of Mechanical Engineering, Michigan State University, MI, USA. Electronic address: lclee@egr.msu.edu.
Samuel T WallSimula Research Laboratory, Oslo, Norway.
Martin GenetDepartment of Surgery, University of California, San Francisco, CA, USA; Department of Bioengineering, University of California, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco, CA, USA; Marie-Curie International Outgoing Fellow, Brussels, Belgium.
Andy HinsonLonestar Heart Inc, Oslo, Norway.
Julius M GuccioneDepartment of Surgery, University of California, San Francisco, CA, USA; Department of Bioengineering, University of California, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco, CA, USA.
University of California, San Francisco · USMichigan State University · USSimula Research Laboratory · NO

Funding

Multi-Scale Laws of Myocardial Growth and RemodelingU01HL119578 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUCCIONE, JULIUS MATTEO, KASSAB, GHASSAN S · 2014 to 2018
$3.8M
VIRTUAL TOOLS FOR CARDIAC VENTRICULAR REMODELING SURGERYR01HL077921 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUCCIONE, JULIUS MATTEO · 2006 to 2015
$3.4M
Minimally Invasive Ventricular Polymeric Injection for Treatment of Heart FailureR01HL118627 · NHLBI · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI GUCCIONE, JULIUS MATTEO, KASSAB, GHASSAN S · 2013 to 2016
$3.0M
NHLBI NIH HHS R01 HL077921NHLBI NIH HHS R01-HL-077921NHLBI NIH HHS R01 HL118627NHLBI NIH HHS R01-HL-118627NHLBI NIH HHS U01 HL119578
6 · The paper itself

Abstract

Injection of biomaterials into diseased myocardium has been associated with decreased myofiber stress, restored left ventricular (LV) geometry and improved LV function. However, its exact mechanism(s) of action remained unclear. In this work, we present the first patient-specific computational model of biomaterial injection that accounts for the possibility of residual strain and stress introduced by this treatment. We show that the presence of residual stress can create more heterogeneous regional myofiber stress and strain fields. Our simulation results show that the treatment generates low stress and stretch areas between injection sites, and high stress and stretch areas between the injections and both the endocardium and epicardium. Globally, these local changes are translated into an increase in average myofiber stress and its standard deviation (from 6.9 ± 4.6 to 11.2 ± 48.8 kPa and 30 ± 15 to 35.1 ± 50.9 kPa at end-diastole and end-systole, respectively). We also show that the myofiber stress field is sensitive to the void-to-size ratio. For a constant void size, the myofiber stress field became less heterogeneous with decreasing injection volume. These results suggest that the residual stress and strain possibly generated by biomaterial injection treatment can have large effects on the regional myocardial stress and strain fields, which may be important in the remodeling process.

Indexed as

Finite Element AnalysisPatient-Specific ModelingStress, MechanicalBiocompatible MaterialsHeart FailureHeart VentriclesHumansInjectionsMyocardiumOrgan SizeBiocompatible MaterialsBiomaterial injectionCongestive heart failureLeft ventricular wall stressMagnetic resonance imagingMathematical modeling

Identifiers

PMID25065728
PMCPMC4163117
OpenAlexW2039598969

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.