Evidence map›Paper›PMID 25065707›Full record

ReviewTrends in microbiology2014

Salmonella chronic carriage: epidemiology, diagnosis, and gallbladder persistence.

John S Gunn, Joanna M Marshall, Stephen Baker, Sabina Dongol, Richelle C Charles, Edward T Ryan

Abstract readReview
In one paragraph

Review in Trends in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 178 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
178citing papers in PubMed, 2 pooled it
16.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

178 citing papers in PubMed, 2 syntheses or guidelines pooled it, 312 citations in OpenAlex.

  1. Risk Factors for Typhoid Fever: Systematic Review.JMIR public health and surveillance · 2025
    Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Autosomal recessiveMolecular genetics and metabolism reports · 2026
    Article
  11. Microorganisms · 2026
    Review
  12. EnhancedInfection and immunity · 2026
    Article
  13. Microorganisms · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

118 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

John S GunnDepartment of Microbial Infection and Immunity, Center for Microbial Interface Biology, The Ohio State University, OH, USA. Electronic address: john.gunn@osumc.edu.
Joanna M MarshallDepartment of Microbial Infection and Immunity, Center for Microbial Interface Biology, The Ohio State University, OH, USA.
Stephen BakerThe Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine, Oxford University, Oxford, United Kingdom; The London School of Hygiene and Tropical Medicine, London, United Kingdom.
Sabina DongolOxford University Clinical Research Unit, Patan Academy of Health Sciences, Kathmandu, Nepal.
Richelle C CharlesDivision of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Edward T RyanDivision of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA.
Harvard University · USThe Ohio State University · USOxford University Clinical Research Unit · VNPatan Academy of Health Sciences · NP

Funding

Protecutive immunity to human cholera in BangladeshU01AI058935 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CALDERWOOD, STEPHEN B., RYAN, EDWARD T. · 2003 to 2014
$7.8M
O-Specific Polysaccharide Responses and CholeraR37AI106878 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Edward T. Ryan · 2020 to 2026
$5.1M
O-Specific Polysaccharide Responses and CholeraR01AI106878 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RYAN, EDWARD T. · 2014 to 2018
$3.7M
Bile, Biofilms and Salmonella Gallbladder CarriageR01AI066208 · NIAID · OHIO STATE UNIVERSITY · PI GUNN, JOHN S · 2007 to 2011
$1.8M
Improving diagnostic capabilities for typhoid feverR33AI100023 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RYAN, EDWARD T. · 2014 to 2016
$987k
O-Specific Polysaccharide Responses and CholeraR56AI106878 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RYAN, EDWARD T. · 2013 to 2020
$843k
High-throughput proteomic study of protective immunity in human cholera infectionK08AI089721 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CHARLES, RICHELLE C · 2010 to 2014
$684k
Chronic infection of the gallbladder by SalmonellaR56AI109002 · NIAID · OHIO STATE UNIVERSITY · PI GUNN, JOHN S · 2014 to 2014
$617k
Improving diagnostic capabilities for typhoid feverR21AI100023 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RYAN, EDWARD T. · 2012 to 2013
$476k
NIAID NIH HHS AI058935NIAID NIH HHS AI066208NIAID NIH HHS AI100023NIAID NIH HHS AI106878NIAID NIH HHS K08 AI089721NIAID NIH HHS R01 AI066208NIAID NIH HHS R01 AI106878NIAID NIH HHS R21 AI100023NIAID NIH HHS R33 AI100023NIAID NIH HHS R37 AI106878NIAID NIH HHS R56 AI106878NIAID NIH HHS R56 AI109002NIAID NIH HHS U01 AI058935Wellcome Trust 100087Wellcome Trust 100087/Z/12/Z
6 · The paper itself

Abstract

Typhoid (enteric fever) remains a major cause of morbidity and mortality worldwide, causing over 21 million new infections annually, with the majority of deaths occurring in young children. Because typhoid fever-causing Salmonella have no known environmental reservoir, the chronic, asymptomatic carrier state is thought to be a key feature of continued maintenance of the bacterium within human populations. Despite the importance of this disease to public health, our understanding of the molecular mechanisms that catalyze carriage, as well as our ability to reliably identify and treat the Salmonella carrier state, have only recently begun to advance.

Indexed as

Host-Pathogen InteractionsCarrier StateGallbladderHumansParatyphoid FeverSalmonella paratyphi ASalmonella typhiTyphoid Feverchronic carrierdiagnosticsepidemiologySalmonellatyphoid fever

Identifiers

PMID25065707
PMCPMC4252485
OpenAlexW1964049648

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.