Evidence map›Paper›PMID 25064780›Full record

ArticleArchives of physical medicine and rehabilitation2014

Ultrasound elastography: the new frontier in direct measurement of muscle stiffness.

Joline E Brandenburg, Sarah F Eby, Pengfei Song, Heng Zhao, Jeffrey S Brault, Shigao Chen, Kai-Nan An

Registry-linked trialAbstract read
In one paragraph

Article in Archives of physical medicine and rehabilitation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05608824 (Evaluation of Lower Extremity Athletic Injuries and Response to Treatment Using Shear Wave Elastography and Micro-vascular Flow Imaging), which is not on this map. Cited by 144 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
144citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05608824 nacompletednot on this mapstarted 2023, after this paper: background citation

Evaluation of Lower Extremity Athletic Injuries and Response to Treatment Using Shear Wave Elastography and Micro-vascular Flow Imaging

TypeinterventionalSponsorOregon Health and Science UniversityRan2023 to 2025Enrolled9ConditionsLower Extremity Musculoskeletal InjuryArmsShear wave elastography and microvascular flow imaging.
3 · Its place in the literature

Who cites it

144 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  12. Evaluation of the Efficacy of Prolotherapy in Patients With Lateral Epicondylitis Using Shear-Wave Elastography.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Observational
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84 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joline E BrandenburgDepartment of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN; Department of Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, MN; Department of Neurology, Mayo Clinic, Rochester, MN. Electronic address: brandenburg.joline@mayo.edu.
Sarah F EbyMayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN; Medical Scientist Training Program, Mayo Clinic, Rochester, MN.
Pengfei SongMayo Graduate School, Mayo Clinic College of Medicine, Rochester, MN.
Heng ZhaoDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN.
Jeffrey S BraultDepartment of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN.
Shigao ChenDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN.
Kai-Nan AnDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN; Division of Orthopedic Research, Mayo Clinic, Rochester, MN.

Funding

Mayo Clinic Center for Translational Science ActivitiesKL2TR000136 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$6.6M
Medical Scientist Traning Program at Mayo ClinicT32GM065841 · NIGMS · MAYO CLINIC ROCHESTER · PI KAUFMANN, SCOTT H, SCHIMMENTI, LISA A · 2003 to 2022
$5.8M
Quantitative evaluation of skeletal muscle passive stiffnessF30AG044075 · NIA · MAYO CLINIC ROCHESTER · PI EBY, SARAH · 2013 to 2016
$158k
NCATS NIH HHS KL2 TR000136NCATS NIH HHS KL2TR000136-07NIA NIH HHS F30 AG044075NIGMS NIH HHS T32 GM065841NIGMS NIH HHS T32 GM 65841
6 · The paper itself

Abstract

The use of brightness-mode ultrasound and Doppler ultrasound in physical medicine and rehabilitation has increased dramatically. The continuing evolution of ultrasound technology has also produced ultrasound elastography, a cutting-edge technology that can directly measure the mechanical properties of tissue, including muscle stiffness. Its real-time and direct measurements of muscle stiffness can aid the diagnosis and rehabilitation of acute musculoskeletal injuries and chronic myofascial pain. It can also help monitor outcomes of interventions affecting muscle in neuromuscular and musculoskeletal diseases, and it can better inform the functional prognosis. This technology has implications for even broader use of ultrasound in physical medicine and rehabilitation practice, but more knowledge about its uses and limitations is essential to its appropriate clinical implementation. In this review, we describe different ultrasound elastography techniques for studying muscle stiffness, including strain elastography, acoustic radiation force impulse imaging, and shear-wave elastography. We discuss the basic principles of these techniques, including the strengths and limitations of their measurement capabilities. We review the current muscle research, discuss physiatric clinical applications of these techniques, and note directions for future research.

Indexed as

Elasticity Imaging TechniquesElasticityHumansMuscle, SkeletalMusculoskeletal DiseasesDiagnostic imagingElasticityHardnessMusclesRehabilitationUltrasonography

Identifiers

PMID25064780
PMCPMC4254343

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.