ArticleEpilepsy & behavior : E&B2014
Validation of the Patient Health Questionnaire-9 (PHQ-9) for depression screening in adults with epilepsy.
Article in Epilepsy & behavior : E&B, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.
- Pooled it
- Telephone-based depression self-management in Hispanic adults with epilepsy: a pilot randomized controlled trial.Translational behavioral medicine · 2021Trial
- Ethnicity and health outcomes among people with epilepsy participating in an epilepsy self-management RCT.Epilepsy & behavior : E&B · 2019Trial
- Depressive Symptom Severity in Individuals With Epilepsy and Recent Health Complications.The Journal of nervous and mental disease · 2019Trial
- The association between high-sensitivity C-reactive protein and depression symptom severity among U.S. adults: A multivariable analysis of NHANES data.Brain, behavior, & immunity - health · 2026Article
- Geographic Disparities in People with Epilepsy: Differences in Self-Efficacy and Quality of Life.Journal of epilepsy research · 2026Article
- What does it mean to live with epilepsy? Burden of illness from the patient perspective.Epilepsia open · 2026Article
- Self-completed patient-reported outcome measures in adults with epilepsy: A review.Epilepsia open · 2026Review
- Modelling risk factors for depressive symptoms in seizure disorders.Therapeutic advances in neurological disorders · 2026Article
- Depression in older adults with epilepsy: Pathophysiology and management considerations.Epilepsy & behavior : E&B · 2025Review
- Mindfulness, coping, and optimism as mechanisms of change in the 3RP-NF intervention.Journal of clinical psychology · 2024Article
- What is the role of screening instruments in the management of psychiatric comorbidities in epilepsy? Tools and practical tips for the most common comorbidities: Depression and anxiety.Epilepsy & behavior reports · 2024Article
- Management of anhedonia after epilepsy surgery.Epilepsy & behavior reports · 2024Article
- Cross-cultural validation of two scales to assess mental wellbeing in persons affected by leprosy in Province 1 and 7, Nepal.PLOS global public health · 2024Article
- Comparison of psychosocial screeners in an epilepsy clinic.Epilepsy & behavior : E&B · 2023Article
- Depression and Associated Factors among Family Caregivers of Children with Disabilities: Analysis of Intergenerational Differences.Healthcare (Basel, Switzerland) · 2023Article
- Article
- Factors associated with stress-related symptoms among people with epilepsy in Ethiopia, a cross-sectional study.Frontiers in neurology · 2023Article
- Article
- Prevalence and associated factors of anxiety disorder symptoms among people with epilepsy in Mekelle, Ethiopia, 2019: Institutional-based cross-sectional study.Nursing open · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThis study aimed to assess the accuracy and operating characteristics of the Patient Health Questionnaire-9 (PHQ-9) for depression screening in adults with epilepsy.
methodsTertiary epilepsy center patients served as the study population, with 237 agreeing to structured interview using the Mini-International Neuropsychiatric Interview (MINI), a "gold standard" instrument developed for rapid diagnosis of neuropsychiatric disorders, including major depressive disorder (MDD); 172 also completed the PHQ-9, and 127 completed both the PHQ-9 and the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) within two days of the MINI. Sensitivity, specificity, positive and negative predictive values, and areas under the ROC curves for each instrument were determined. Cut-points of 10 for the PHQ-9 and 15 for the NDDI-E were used, and ratings at or above the cut-points were considered screen-positive. The PHQ-9 was divided into cognitive/affective (PHQ-9/CA) and somatic (PHQ-9/S) subscales to determine comparative depression screening accuracy.
resultsThe calculated areas under the ROC curves for the PHQ-9 (n=172) and the PHQ-9/CA and PHQ-9/S subscales were 0.914, 0.924, and 0.846, respectively, with the PHQ-9 more accurate than the PHQ-9/S (p=0.002) but not different from the PHQ-9/CA (p=0.378). At cut-points of 10 and 15, respectively, the PHQ-9 had higher sensitivity (0.92 vs 0.87) but lower specificity (0.74 vs 0.89) compared with the NDDI-E. The areas under the ROC curves of the PHQ-9 and the NDDI-E showed similar accuracy (n=127; 0.930 vs 0.934; p=0.864). SIGNIFICANCE: The PHQ-9 is an efficient and nonproprietary depression screening instrument with excellent accuracy validated for use in adult patients with epilepsy as well as multiple other medical populations.
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Registered trials
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