Evidence map›Paper›PMID 25064711›Full record

ReviewHematology/oncology clinics of North America2014

Use of magnetic resonance imaging to monitor iron overload.

John C Wood

Abstract readReview
In one paragraph

Review in Hematology/oncology clinics of North America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Elucidating Iron Metabolism through Molecular Imaging.Current issues in molecular biology · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

John C WoodDepartment of Pediatrics, Children's Hospital, Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA; Department of Radiology, Children's Hospital, Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA. Electronic address: jwood@chla.usc.edu.

Funding

ZOPOLRESTAT IN NORMOTENSIVE, TYPE 1 DIA WITH INCIPIENT NEPHROPATHYM01RR000043 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZAIA, JOHN A · 1985 to 2010
$76.4M
Cardiac Function and Cardiac iron (T2*) in ThalassemiaR01HL075592 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI WOOD, JOHN C · 2004 to 2007
$1.6M
Optimizing Tissue Iron Quantification at 3 TeslaR01DK097115 · NIDDK · CHILDREN'S HOSPITAL OF LOS ANGELES · PI WOOD, JOHN C · 2013 to 2016
$1.6M
Iron-mediated vascular disease in sickle cell disease.RC1HL099412 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI WOOD, JOHN C · 2009 to 2010
$995k
NCRR NIH HHS M01 RR000043NHLBI NIH HHS R01 HL075592NHLBI NIH HHS RC1 HL099412NIDDK NIH HHS R01 DK097115
6 · The paper itself

Abstract

Treatment of iron overload requires robust estimates of total-body iron burden and its response to iron chelation therapy. Compliance with chelation therapy varies considerably among patients, and individual reporting is notoriously unreliable. Even with perfect compliance, intersubject variability in chelator effectiveness is extremely high, necessitating reliable iron estimates to guide dose titration. In addition, each chelator has a unique profile with respect to clearing iron stores from different organs. This article presents the tools available to clinicians to monitor their patients, focusing on noninvasive magnetic resonance imaging methods because they have become the de facto standard of care.

Indexed as

Magnetic Resonance ImagingBiomarkersHumansIronIron OverloadKidneyLiverMyocardiumPancreasSpleenBiomarkersIronChelationHeartIronIron overloadLiverMagnetic resonance imagingSickle cell diseaseThalassemia

Identifiers

PMID25064711
PMCPMC4115249

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.