ReviewMolecular and biochemical parasitology2014
The role of PfEMP1 adhesion domain classification in Plasmodium falciparum pathogenesis research.
Review in Molecular and biochemical parasitology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 99 citations in OpenAlex.
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- Recrudescent severe malaria due to Plasmodium falciparum following treatment in a Taiwanese patient: a case report.Malaria journal · 2025Article
- ICAM-1 autoantibodies detected in healthy individuals and cross-react with functional epitopes.ImmunoHorizons · 2025Article
- Genome-wide gene expression profiles throughout human malaria parasite liver stage development in humanized mice.Nature microbiology · 2025Article
- Comparative genomics of two protozoansHeliyon · 2024Article
- Transcriptional responses of brain endothelium toMicrobiology spectrum · 2024Article
- A paradoxical population structure ofbioRxiv : the preprint server for biology · 2023Article
- Different PfEMP1-expressing Plasmodium falciparum variants induce divergent endothelial transcriptional responses during co-culture.PloS one · 2023Article
- Varia: a tool for prediction, analysis and visualisation of variable genes.BMC bioinformatics · 2022Article
- Binding of Plasmodium falciparum-Infected Red Blood Cells to Engineered 3D Microvessels.Methods in molecular biology (Clifton, N.J.) · 2022Article
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- Malaria Parasite Plasmodium falciparum Proteins on the Surface of Infected Erythrocytes as Targets for Novel Drug Discovery.Biochemistry. Biokhimiia · 2022Review
- Host-directed therapy, an untapped opportunity for antimalarial intervention.Cell reports. Medicine · 2021Review
- Determinants of brain swelling in pediatric and adult cerebral malaria.JCI insight · 2021Article
- Antibody Levels to Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLγ11 and DBLδ-1 Predict Reduction in Parasite Density.mSystems · 2021Article
- Bioengineered 3D Microvessels for Investigating Plasmodium falciparum Pathogenesis.Trends in parasitology · 2021Review
- Antibody mediated activation of natural killer cells in malaria exposed pregnant women.Scientific reports · 2021Article
- Congenital Transmission of Apicomplexan Parasites: A Review.Frontiers in microbiology · 2021Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family has a key role in parasite survival, transmission, and virulence. PfEMP1 are exported to the erythrocyte membrane and mediate binding of infected erythrocytes to the endothelial lining of blood vessels. This process aids parasite survival by avoiding spleen-dependent killing mechanisms, but it is associated with adhesion-based disease complications. Switching between PfEMP1 proteins enables parasites to evade host immunity and modifies parasite tropism for different microvascular beds. The PfEMP1 protein family is one of the most diverse adhesion modules in nature. This review covers PfEMP1 adhesion domain classification and the significant role it is playing in deciphering and deconvoluting P. falciparum cytoadhesion and disease.
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