Evidence map›Paper›PMID 25064553›Full record

ReviewAdvanced drug delivery reviews2014

Fluorescent imaging of cancerous tissues for targeted surgery.

Lihong Bu, Baozhong Shen, Zhen Cheng

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced drug delivery reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03931044 (Fluorescence Image-Guided Lymphadenectomy Using Indocyanine Green and Near Infrared Technology in Robotic Gastrectomy), which is not on this map. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03931044 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Fluorescence Image-Guided Lymphadenectomy Using Indocyanine Green and Near Infrared Technology in Robotic Gastrectomy

TypeinterventionalSponsorInternational Study Group on Minimally Invasive Surgery for Gastric CancerRan2019 to 2020Enrolled40ConditionsGastric Cancer, Sentinel Lymph NodeArmsImage-Guided Robotic Gastrectomy
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  7. Current Trends in Gastric Cancer Surgery and Postoperative Care.The Korean journal of helicobacter and upper gastrointestinal research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lihong BuMolecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University, 1201 Welch Road, Lucas Center, Room P095, Stanford, CA 94305-5484, USA; Molecular Imaging Center, Department of Radiology, The 4th hospital of Harbin Medical University, No 31 Yiyuan Street, Nangang District, Harbin, Heilongjiang 150001, PR China.
Baozhong ShenMolecular Imaging Center, Department of Radiology, The 4th hospital of Harbin Medical University, No 31 Yiyuan Street, Nangang District, Harbin, Heilongjiang 150001, PR China. Electronic address: shenbzh@vip.sina.com.
Zhen ChengMolecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University, 1201 Welch Road, Lucas Center, Room P095, Stanford, CA 94305-5484, USA. Electronic address: zcheng@stanford.edu.

Funding

Small Animal ImagingP50CA114747 · NCI · STANFORD UNIVERSITY · PI RAO, JIANGHONG · 2005 to 2014
$18.2M
NCI NIH HHS P50 CA114747
6 · The paper itself

Abstract

To maximize tumor excision and minimize collateral damage are the primary goals of cancer surgery. Emerging molecular imaging techniques have made "image-guided surgery" developed into "molecular imaging-guided surgery", which is termed as "targeted surgery" in this review. Consequently, the precision of surgery can be advanced from tissue-scale to molecule-scale, enabling "targeted surgery" to be a component of "targeted therapy". Evidence from numerous experimental and clinical studies has demonstrated significant benefits of fluorescent imaging in targeted surgery with preoperative molecular diagnostic screening. Fluorescent imaging can help to improve intraoperative staging and enable more radical cytoreduction, detect obscure tumor lesions in special organs, highlight tumor margins, better map lymph node metastases, and identify important normal structures intraoperatively. Though limited tissue penetration of fluorescent imaging and tumor heterogeneity are two major hurdles for current targeted surgery, multimodality imaging and multiplex imaging may provide potential solutions to overcome these issues, respectively. Moreover, though many fluorescent imaging techniques and probes have been investigated, targeted surgery remains at a proof-of-principle stage. The impact of fluorescent imaging on cancer surgery will likely be realized through persistent interdisciplinary amalgamation of research in diverse fields.

Indexed as

Optical ImagingSurgery, Computer-AssistedAnimalsFluorescent DyesHumansNeoplasmsFluorescent DyesFluorescent imagingImage-guided surgeryMolecular imagingMultimodality imagingMultiplex imagingSystem molecular imagingTargeted surgeryTargeted therapy

Identifiers

PMID25064553
PMCPMC4169718

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.