ArticleInternational journal of colorectal disease2014
Evaluation of four comorbidity indices and Charlson comorbidity index adjustment for colorectal cancer patients.
Article in International journal of colorectal disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Article
- Comorbidities among American Indian and Alaska Native People with Cancer: A Surveillance, Epidemiology, and End Results-Medicare Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Charlson-Deyo Index Impact on Overall Survival After Surgery for Sinonasal Squamous Cell Carcinoma.Laryngoscope investigative otolaryngology · 2025Article
- Gravida and Birth Outcomes Prior to and after Diagnosis of Early Age-Onset Colorectal Cancer among Female Patients: Population-Based Epidemiologic Studies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Sexual health outcomes after colorectal cancer diagnosis in females: a population-based cohort study.Journal of the National Cancer Institute · 2025Article
- Explainable machine learning model for prediction of 28-day all-cause mortality in immunocompromised patients in the intensive care unit: a retrospective cohort study based on MIMIC-IV database.European journal of medical research · 2025Article
- The role of enteral nutrition in cancer patients - methodological adjustments and recommendations.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- A Retrospective Claims Analysis of the Rate of Complications in Patients Undergoing Treatment for Paroxysmal Nocturnal Hemoglobinuria.Advances in therapy · 2025Article
- Age-adjusted Charlson comorbidity index and its association with body composition and overall survival in patients with colorectal cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Comparing Charlson Comorbidity Index Scores between Anesthesiologists, Patients, and Administrative Data: A Prospective Observational Study.Journal of clinical medicine · 2024Article
- The disproportionate burden of Alzheimer's disease and related dementias (ADRD) in diverse older adults diagnosed with cancer.Journal of geriatric oncology · 2023Article
- Examining the continuum of resistance model in two population-based screening studies in Sweden.Preventive medicine reports · 2023Article
- Effectiveness and Safety of Endoscopic Submucosal Dissection for Colorectal Neoplasm in Patients with High Charlson Comorbidity Index Score: A HASID Multicenter Study.Journal of clinical medicine · 2023Article
- Multimorbidity in people living with and beyond cancer: a scoping review.American journal of cancer research · 2023Article
- Impact of Tumor Location on Survival in Patients With Colorectal Cancer: A Retrospective Cohort Study Based on Taiwan's Cancer Registry Database.Clinical Medicine Insights. Oncology · 2022Article
- Impact of Age and Comorbidity on Multimodal Management and Survival from Colorectal Cancer: A Population-Based Study.Journal of clinical medicine · 2021Article
- Prognostic factors for stage III colon cancer in patients 80 years of age and older.International journal of colorectal disease · 2021Article
- The use of neoadjuvant lobar radioembolization prior to major hepatic resection for malignancy results in a low rate of post hepatectomy liver failure.Journal of gastrointestinal oncology · 2021Article
- Recurrence, death risk, and related factors in patients with stage 0 colorectal cancer: A nationwide population-based study.Medicine · 2020Article
- Real-world impact of laparoscopic surgery for rectal cancer: a population-based analysis.Current oncology (Toronto, Ont.) · 2020Article
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Authors and funding
11 authors.
Funding
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Abstract
introductionCancer survival is related not only to primary malignancy but also to concomitant nonmalignant diseases. The aim of this study was to investigate the prognostic capacity of four comorbidity indices [the Charlson comorbidity index (CCI), the Elixhauser method, the National Institute on Aging (NIA) and National Cancer Institute (NCI) comorbidity index, and the Adult Comorbidity Evaluation-27 (ACE-27)] for both cancer-related and all-cause mortality among colorectal cancer patients. A modified version of the CCI adapted for colorectal cancer patients was also built.
methodsThe study population comprised 468 cases of colorectal cancer diagnosed between 1 January 2000 and 31 December 2010 at a community hospital. Data were prospectively collected and abstracted from patients' clinical records. Kaplan-Meier method and multivariate logistic regression models were performed for survival and risk of death analysis.
resultsOnly moderate or severe renal disease [hazard ratio (HR) 2.71, 95% confidence interval (CI) 1.11-6.63] and AIDS (HR 3.27, 95% CI 1.23-8.68) were independently associated with cancer-specific mortality, with a population attributable risk of 5.18 and 4.36%, respectively. For each index, the highest comorbidity burden was significantly associated with poorer overall survival (NIA/NCI: HR 2.14, 95% CI 1.14-4.01; Elixhauser: HR 1.98, 95% CI 1.09-1.42; ACE-27: HR 1.78, 95% CI 1.07-1.23; CCI: HR 1.68, 95% CI 1.05-1.42) and cancer-specific survival. The modified version of the CCI resulted in a higher predictive power compared with other indices studied (cancer-specific mortality HR = 2.37, 95% CI 1.37-4.08).
conclusionsThe comorbidity assessment tools provided better prognostic prevision of prospective outcome of colorectal cancer patients than single comorbid conditions.
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