ArticlePituitary2015
Extracapsular en bloc resection in pituitary adenoma surgery.
Article in Pituitary, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- The incidence of postoperative cerebrospinal fluid leakage after elective cranial surgery: a systematic review.Neurosurgical review · 2022Pooled it
- Comparison of outcomes between intracapsular resection and pseudocapsule-based extracapsular resection for pituitary adenoma: a systematic review and meta-analysis.BMC neurology · 2022Pooled it
- Co-secretion of growth hormone and prolactin defines a high-risk acromegaly phenotype.Pituitary · 2026Article
- Rapid intraoperative boundary diagnosis of somatotroph pituitary neuroendocrine tumors using real-time PCR.Acta neuropathologica communications · 2026Article
- Surgical Strategies for Giant Pituitary Adenomas to Minimize Postoperative Hematoma Formation.Neurologia medico-chirurgica · 2025Article
- Extracapsular Resection of Pituitary Adenomas: A Systematic Review.Asian journal of neurosurgery · 2023Review
- Endoscopic endonasal surgery for non-invasive pituitary neuroendocrinology tumors with incomplete pseudocapsule.Frontiers in neurology · 2023Article
- Arachnoid Remodeling by Clipping Technique Facilitates Surgical Maneuverability during Transsphenoidal Surgery for Pituitary Macroadenoma.Journal of Korean Neurosurgical Society · 2022Article
- Pseudocapsule and pseudocapsule-based extracapsular resection in pituitary neuroendocrine tumors.Frontiers in endocrinology · 2022Review
- Sellar and parasellar lesions: multidisciplinary management.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2021Article
- Pseudocapsule-Based Resection for Pituitary AdenomasFrontiers in oncology · 2021Article
- Precision Therapy in Acromegaly Caused by Pituitary Tumors: How Close Is It to Reality?Endocrinology and metabolism (Seoul, Korea) · 2020Review
- Perilesional Resection of Glioblastoma Is Independently Associated With Improved Outcomes.Neurosurgery · 2020Observational
- Peel-off resection of the pituitary gland for functional pituitary adenomas: pathological significance and impact on pituitary function.Pituitary · 2019Article
- Clinical Significance of Radical Surgery in the Treatment of Silent Corticotroph Adenoma.Journal of Korean Neurosurgical Society · 2019Article
- Effects of preoperative bromocriptine treatment on prolactin-secreting pituitary adenoma surgery.Experimental and therapeutic medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeA pituitary pseudocapsule often contains tumor tissue and should be removed for radical resection. It can be used as a surgical plane for more radical resection of the tumor in many cases of pituitary adenomas. We evaluated the advantages and disadvantages of extracapsular en bloc capsulectomy.
methodsFrom 1992 until 2011, 1,089 treated patients were grouped according to the resection technique: en bloc capsulectomy, fragmented capsulectomy, or piecemeal resection. Their surgical and endocrinological outcomes and complications were evaluated.
resultsExtracapsular tumor resection was performed in 263 patients; en bloc capsulectomy in 94 patients and fragmented capsulectomy in 169, whereas piecemeal resection was performed in 826. Extracapsular resection was performed more frequently in prolactin- and thyroid-stimulating hormone-secreting tumors. Total resection was more frequently achieved in extracapsular resection and its chance was 100% when tumors were removed in an en bloc fashion. For the functioning pituitary adenomas, endocrinological remission was achieved in all patients whose tumors were removed in an en bloc fashion and there was no recurrence. Postoperative cerebrospinal fluid (CSF) rhinorrhea developed in 4.2 and 2.7% in the extracapsular resection group and the piecemeal resection groups, respectively. The chance of postoperative aggravation of pituitary function was not statistically different between groups.
conclusionsExtracapsular resection is critical for radical tumor resection and endocrinological remission. The removal of a pseudocapsule does not increase the risk of postoperative hypopituitarism nor postoperative CSF rhinorrhea.
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