Evidence map›Paper›PMID 25063986›Full record

ReviewCurrent opinion in virology2014

Virus interactions with endothelial cell receptors: implications for viral pathogenesis.

Nadine A Dalrymple, Erich R Mackow

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Utility of NO and HNitric oxide : biology and chemistry · 2022
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Host-virus interaction and viral evasion.Cell biology international · 2021
    Review
  9. The Immune Correlates ofVaccines · 2021
    Review
  10. Article
  11. Endothelial Cells in Emerging Viral Infections.Frontiers in cardiovascular medicine · 2021
    Review
  12. Article
  13. Review
  14. Article
  15. Antiviral anticoagulation.Research and practice in thrombosis and haemostasis · 2020
    Review
  16. Orthohantavirus Pathogenesis and Cell Tropism.Frontiers in cellular and infection microbiology · 2020
    Review
  17. Article
  18. Virus envelope tissue factor promotes infection in mice.Journal of thrombosis and haemostasis : JTH · 2019
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nadine A DalrympleStony Brook University, United States.
Erich R MackowStony Brook University, United States. Electronic address: Erich.Mackow@stonybrook.edu.
Stony Brook University · US

Funding

Viral Pathogenesis and TherapeuticsU54AI057158 · NIAID · WADSWORTH CENTER · PI LEVY, DAVID E · 2003 to 2014
$100.8M
Therapeutic Interventions Against ANDV Induced PathogenesisR01AI093792 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI MACKOW, ERICH R · 2012 to 2016
$2.2M
HANTAVIRUS CELL INTERACTIONSR01AI047873 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI MACKOW, ERICH R. · 2000 to 2003
$1.1M
Determinants of Pathogenic Hantavirus AttachmentR21AI080984 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI MACKOW, ERICH R · 2009 to 2010
$430k
Dengue Infected Endothelial Cells Enhance Immune Cell ActivationR21AI097951 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI MACKOW, ERICH R · 2012 to 2013
$418k
NIAID NIH HHS AI093792NIAID NIH HHS AI097951NIAID NIH HHS AI1092191NIAID NIH HHS AI75022NIAID NIH HHS R01 AI047873NIAID NIH HHS R01 AI093792NIAID NIH HHS R21 AI080984NIAID NIH HHS R21 AI097951NIAID NIH HHS U54AI57158
6 · The paper itself

Abstract

The endothelial lining of the vasculature performs a vital role in maintaining fluid barrier functions despite balancing nutrient and fluid content of tissues, repairing localized damage, coordinating responses of a plethora of factors, immune cells and platelets through a multitude of endothelial cell surface receptors. Viruses that nonlytically cause lethal hemorrhagic or edematous diseases engage receptors on vascular and lymphatic endothelial cells, altering normal cellular responses that control capillary leakage and fluid clearance functions with lethal consequences. Recent studies indicate that receptors directing dengue virus and hantavirus infection of the endothelium contribute to the dysregulation of normal endothelial cell signaling responses that control capillary permeability and immune responses that contribute to pathogenesis. Here we present recent studies of virally altered endothelial functions that provide new insight into targeting barrier functions of the endothelium as a potential therapeutic approach.

Indexed as

AnimalsDengueDengue VirusEndothelial CellsHantavirus InfectionsHumansOrthohantavirusReceptors, VirusReceptors, Virus

Identifiers

PMID25063986
PMCPMC4206553
OpenAlexW1976036131

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.