ArticleAmerican journal of physiology. Heart and circulatory physiology2014
The low frequency power of heart rate variability is neither a measure of cardiac sympathetic tone nor of baroreflex sensitivity.
Article in American journal of physiology. Heart and circulatory physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 99 citations in OpenAlex.
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- Quantitative assessment of the relationship between behavioral and autonomic dynamics during propofol-induced unconsciousness.PloS one · 2021Trial
- The effects of yoga and quiet rest on subjective levels of anxiety and physiological correlates: a 2-way crossover randomized trial.BMC complementary and alternative medicine · 2018Trial
- Conditional Self-Entropy and Conditional Joint Transfer Entropy in Heart Period Variability during Graded Postural Challenge.PloS one · 2015Trial
- Heart rate variability as a strain parameter in maritime settings: a scoping review of methodological approaches to data collection and analysis in field studies on the high seas.Journal of occupational medicine and toxicology (London, England) · 2026Review
- Decreased and Increased Baroreceptor Sensitivity Are Associated With Incident Heart Failure in the Elderly: A 15-Year Follow-Up Study.Clinical cardiology · 2026Article
- Shared autonomic phenotype of long COVID and myalgic encephalomyelitis/chronic fatigue syndrome.PloS one · 2026Article
- Peripheral catecholamine systems: an evolutionary perspective.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Review
- Vasomotor symptoms of menopause, sympathetic activity, and blood pressure in postmenopausal females.American journal of physiology. Heart and circulatory physiology · 2025Article
- Higher hemoglobin levels are associated with adverse heart rate variability in a middle-aged birth cohort.Physiological reports · 2025Article
- Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Hemodynamics and Autonomic Function During Exercise Stress Tests in Healthy Volunteers.Circulation reports · 2025Article
- Wearable sensors for monitoring caregivers of people with dementia: a scoping review.European geriatric medicine · 2025Article
- Comprehensive linear and nonlinear heart rate variability normative data in children.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- De-stress your physiological activation by compressing your imagination: a brief session of hypnosis decreases sympathetic stress response in moderately stressed dentists.Frontiers in psychology · 2025Article
- Cardiovascular function and autonomic regulation in urethane-anesthetized and conscious mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- How does fetal inflammatory response syndrome change fetal response to hypoxia? An experimental study in a fetal sheep model.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Aberrant brain-heart coupling is associated with the severity of post cardiac arrest brain injury.Annals of clinical and translational neurology · 2024Article
- Altered Low Frequency Heart Rate Variability Associated with Agoraphobia in Panic Disorder: A Retrospective Study.Yonsei medical journal · 2023Article
- The Validity of Ultra-Short-Term Heart Rate Variability during Cycling Exercise.Sensors (Basel, Switzerland) · 2023Article
- Severity identification for internet gaming disorder using heart rate variability reactivity for gaming cues: a deep learning approach.Frontiers in psychiatry · 2023Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lack of noninvasive approaches to measure cardiac sympathetic nerve activity (CSNA) has driven the development of indirect estimates such as the low-frequency (LF) power of heart rate variability (HRV). Recently, it has been suggested that LF HRV can be used to estimate the baroreflex modulation of heart period (HP) rather than cardiac sympathetic tone. To test this hypothesis, we measured CSNA, HP, blood pressure (BP), and baroreflex sensitivity (BRS) of HP, estimated with the modified Oxford technique, in conscious sheep with pacing-induced heart failure and in healthy control sheep. We found that CSNA was higher and systolic BP and HP were lower in sheep with heart failure than in control sheep. Cross-correlation analysis showed that in each group, the beat-to-beat changes in HP correlated with those in CSNA and in BP, but LF HRV did not correlate significantly with either CSNA or BRS. However, when control sheep and sheep with heart failure were considered together, CSNA correlated negatively with HP and BRS. There was also a negative correlation between CSNA and BRS in control sheep when considered alone. In conclusion, we demonstrate that in conscious sheep, LF HRV is neither a robust index of CSNA nor of BRS and is outperformed by HP and BRS in tracking CSNA. These results do not support the use of LF HRV as a noninvasive estimate of either CSNA or baroreflex function, but they highlight a link between CSNA and BRS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.