ArticleAging2014
WI-38 senescence is associated with global and site-specific hypomethylation.
Article in Aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Genomic, epigenomic and transcriptomic regulation of cellular senescence.Nature reviews. Genetics · 2026Review
- Significance of Circulating Cell-Free DNA Biomarkers in HBeAg-Negative Chronic Hepatitis B Virus Infection and Their Changes after Treatment Initiation.Pathogens (Basel, Switzerland) · 2023Article
- Article
- Modeling of the Senescence-Associated Phenotype in Human Skin Fibroblasts.International journal of molecular sciences · 2022Article
- CBX4 Regulates Replicative Senescence of WI-38 Fibroblasts.Oxidative medicine and cellular longevity · 2022Article
- DNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift.Communications biology · 2021Article
- The road ahead for health and lifespan interventions.Ageing research reviews · 2020Review
- Age-related Changes in the Global DNA Methylation Profile of Oligodendrocyte Progenitor Cells Derived from Rat Spinal Cords.Current medical science · 2019Article
- Global methylation correlates with clinical status in multiple sclerosis patients in the first year of IFNbeta treatment.Scientific reports · 2017Article
- Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Epigenetic Regulation of Cellular Senescence and Aging.Frontiers in genetics · 2017Review
- The histone methyltransferase G9a as a therapeutic target to override gemcitabine resistance in pancreatic cancer.Oncotarget · 2016Article
- Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence.Biological research · 2016Article
- The Impact of External Factors on the Epigenome: In Utero and over Lifetime.BioMed research international · 2016Review
- Epigenetic alterations in the suprachiasmatic nucleus and hippocampus contribute to age-related cognitive decline.Oncotarget · 2015Review
- Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk.Clinical epigenetics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular senescence plays an important role in the age-dependent functional decline of organs and organ systems, as well as in age-related pathologies, such as cancer. Therefore, a better understanding of its underlying molecular mechanisms is crucial in the search for intervening measures. In this study, we considered the role of DNA methylation in senescence. We found that senescence is associated with global DNA hypomethylation, but also involves site-specific DNA hypo- and hypermethylation. In some cases, this differential methylation may affect gene expression and thereby modulate functional processes within cells. However, the majority of the CpG sites that were differentially methylated did not correspond with altered gene expression, suggesting that DNA methylation affects senescence by other means also, such as, for instance, genome stability.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.