Evidence map›Paper›PMID 25063755›Full record

ReviewThe Journal of endocrinology2014

20 years of leptin: role of leptin in energy homeostasis in humans.

Michael Rosenbaum, Rudolph L Leibel

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00265980 (Leptin in Human Energy and Neuroendocrine Homeostasis), which is not on this map. Cited by 125 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
125citing papers in PubMed, 2 pooled it
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00265980 naterminatednot on this map

Leptin in Human Energy and Neuroendocrine Homeostasis

TypeinterventionalSponsorColumbia UniversityRan2002 to 2013Enrolled22ConditionsObesity, Weight LossArmsSubcutaneous Placebo, Leptin
3 · Its place in the literature

Who cites it

125 citing papers in PubMed, 2 syntheses or guidelines pooled it, 241 citations in OpenAlex.

  1. Pooled it
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  11. Examining the Role of Sleep in Body Weight Regulation and Implications for Obesity Treatment: A Narrative Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
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65 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Michael RosenbaumDivision of Molecular GeneticsDepartments of Pediatrics and Medicine, College of Physicians and Surgeons, Columbia University, Russ Berrie Medical Science Pavilion, 6th Floor, 1150 St Nicholas Avenue, New York, New York 10032, USA mr475@columbia.edu.
Rudolph L LeibelDivision of Molecular GeneticsDepartments of Pediatrics and Medicine, College of Physicians and Surgeons, Columbia University, Russ Berrie Medical Science Pavilion, 6th Floor, 1150 St Nicholas Avenue, New York, New York 10032, USA.
Columbia University · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
WOUND HEALING IN INDIVIDUALS OF DIFFERENT AGE AND GENETIC BACKGROUNDM01RR000102 · NCRR · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY · 1985 to 2006
$32.8M
ZOLEDRONIC ACID IN PROSTATE CANCERM01RR000645 · NCRR · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI COLTEN, HARVEY R · 1985 to 2006
$27.0M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
WORKSHOP ON ADVANCES IN MUSCULOSKELETAL MRIP41RR002305 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI SONG, HEE KWON · 1985 to 2011
$14.7M
THERMOGENESIS AND EXERCISE IN LEAN, OBESE, AND DIABETICR01DK037948 · NIDDK · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI KLEIN, SAMUEL · 1987 to 2012
$4.6M
Leptin in Human Energy and Neuroendocrine HomeostasisR01DK064773 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEIBEL, RUDOLPH L · 2003 to 2013
$3.3M
ENERGY HOMEOSTASIS IN HUMAN OBESITYR01DK030583 · NIDDK · ROCKEFELLER UNIVERSITY · PI LEIBEL, RUDOLPH L · 1986 to 2001
$514k
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1TR00040NCRR NIH HHS M01 RR000102NCRR NIH HHS M01 RR000645NCRR NIH HHS P41 RR002305NCRR NIH HHS RR00102NCRR NIH HHS RR00645NCRR NIH HHS RR024156NCRR NIH HHS UL1 RR024156NIDDK NIH HHS DK26687NIDDK NIH HHS DK30583,NIDDK NIH HHS DK37948NIDDK NIH HHS DK64773NIDDK NIH HHS P30 DK026687NIDDK NIH HHS R01 DK037948NIDDK NIH HHS R01 DK064773PHS HHS DKP30 26687
6 · The paper itself

Abstract

The hyperphagia, low sympathetic nervous system tone, and decreased circulating concentrations of bioactive thyroid hormones that are common to states of congenital leptin deficiency and hypoleptinemia following and during weight loss suggest that the major physiological function of leptin is to signal states of negative energy balance and decreased energy stores. In weight-reduced humans, these phenotypes together with pronounced hypometabolism and increased parasympathetic nervous system tone create the optimal circumstance for weight regain. Based on the weight loss induced by leptin administration in states of leptin deficiency (obese) and observed similarity of phenotypes in states of congenital and dietary-induced states of hypoleptinemia (reduced obese), it has been suggested that exogenous leptin could potentially be useful in initiating, promoting, and sustaining weight reduction. However, the responses of human beings to exogenous leptin administration are dependent not only on extant energy stores but also on energy balance. Leptin administration to humans at usual weight has little, if any, effect on body weight while leptin administration during weight loss mitigates hunger, especially if given in supraphysiological doses during severe caloric restriction. Leptin repletion is most effective following weight loss by dietary restriction. In this state of weight stability but reduced energy stores, leptin at least partially reverses many of the metabolic, autonomic, neuroendocrine, and behavioral adaptations that favor weight regain. The major physiological function of leptin is to signal states of negative energy balance and decreased energy stores. Leptin, and pharmacotherapies affecting leptin signaling pathways, is likely to be most useful in sustaining weight loss.

Indexed as

Body WeightEnergy MetabolismHomeostasisHumansLeptinModels, BiologicalObesitySignal TransductionLeptinenergyleptinmetabolismobesity

Identifiers

PMID25063755
PMCPMC4454393
OpenAlexW1970070704

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.