ArticleJournal of clinical epidemiology2014
Distinct trajectories of multimorbidity in primary care were identified using latent class growth analysis.
Article in Journal of clinical epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Multimorbidity and consultation time: a systematic review.BMC family practice · 2020Pooled it
- Beyond Return to Work: The Effect of Multimorbidity on Work Functioning Trajectories After Sick Leave due to Common Mental Disorders.Journal of occupational rehabilitation · 2017Trial
- Bridging Population Patterns and Individual Prediction: Framework for Prospective Multimorbidity Study.JMIR medical informatics · 2026Article
- Longitudinal pattern of multimorbidity in older adult population: latent transition analysis in 34 countries.American journal of epidemiology · 2026Article
- Infant vaccination coverage trajectories and immunisation system archetypes in the WHO African region, 2019-2024: a longitudinal analysis of 47 countries.BMJ public health · 2026Article
- Long-term accrual of conditions following myocardial infarction: a study of disease trajectories in the Wales Multimorbidity e-Cohort.BMC medicine · 2025Article
- Longitudinal Trajectories of Multimorbidity and Psychosocial Resilience Resources in Midlife and Older Adults: Findings From the Health and Retirement Study.Journal of aging and health · 2025Article
- Exploring population and sex-specific disease trajectories for multimorbidities among individuals with overweight or obesity: A retrospective cohort study in UK biobank.Diabetes, obesity & metabolism · 2025Article
- Examining lifestyle factors as potential moderators of the link between childhood adversity and comorbid psychological distress and obesity in early adulthood.BMC public health · 2025Article
- Charting the Pathways of Cardiometabolic Multimorbidity: A Systematic Review of Clinical Trajectories.Journal of clinical medicine · 2025Review
- Identifying and Understanding Use Trajectories of Cigarettes and E-Cigarettes.Substance use & misuse · 2025Article
- Musculoskeletal Multimorbidity Burden and Trajectory in Relation to Later-Life Holistic Well-Being Among Middle-Aged and Elderly Individuals: A Prospective Study.Orthopaedic surgery · 2024Article
- Chronic condition change and its longitudinal association with health care utilization among rural older adults: intergenerational financial support as a possible moderator?BMC geriatrics · 2024Article
- Association of physical activity trajectories over 8 years and risk of knee replacement: data from the osteoarthritis initiative.BMC musculoskeletal disorders · 2024Article
- Article
- Twenty-year trajectories of morbidity in individuals with and without osteoarthritis.RMD open · 2024Article
- Factors associated with trajectories of bone marrow lesions over 4 years: data from the Osteoarthritis Initiative.Skeletal radiology · 2024Article
- Article
- Unraveling cradle-to-grave disease trajectories from multilayer comorbidity networks.NPJ digital medicine · 2024Article
- Association between household solid fuel usage and trajectories of multimorbidity among middle-aged and older adults: a nationwide population-based cohort study.Frontiers in public health · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo investigate the use of latent class growth analysis (LCGA) in understanding onset and changes in multimorbidity over time in older adults. STUDY DESIGN AND
settingThis study used primary care consultations for 42 consensus-defined chronic morbidities over 3 years (2003-2005) by 24,615 people aged >50 years at 10 UK general practices, which contribute to the Consultations in Primary Care Archive database. Distinct groups of people who had similar progression of multimorbidity over time were identified using LCGA. These derived trajectories were tested in another primary care consultation data set with linked self-reported health status.
resultsFive clusters of people representing different trajectories were identified: those who had no recorded chronic problems (40%), those who developed a first chronic morbidity over 3 years (10%), a developing multimorbidity group (37%), a group with increasing number of chronic morbidities (12%), and a multi-chronic group with many chronic morbidities (1%). These trajectories were also identified using another consultation database and associated with self-reported physical and mental health.
conclusionThere are distinct trajectories in the development of multimorbidity in primary care populations, which are associated with poor health. Future research needs to incorporate such trajectories when assessing progression of disease and deterioration of health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.