Trial reportDer Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft2014
[New aspects in the therapy of multiple sclerosis and optic neuritis].
Trial report in Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01962571 (Treatment of Optic Neuritis With Erythropoietin), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment of Optic Neuritis With Erythropoietin: a Randomised, Double-blind, Placebo-controlled Trial
Who cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the success of recently introduced immunomodulatory therapies, multiple sclerosis and its ophthalmic manifestation as optic neuritis lead to irreversible axonal degeneration. Hence, it would be desirable to apply a neuroprotective therapy in parallel. RESULTS AND DISCUSSION: We identified erythropoietin as an available and approved drug exerting neuroprotective effects in addition to its hematopoetic action. After several successful preclinical experiments, the pilot trial VISION PROTECT has shown that 33,000 IU erythropoietin, given intravenously on 3 consecutive days, preserves the retinal nerve fibre layer to a significant extent. This therapy will now be evaluated in a full scale and adequately powered trial to challenge this hypothesis. The TONE trial (Treatment of Optic Neuritis with Erythropoietin, NCT01962571) is a multicentric, prospective, double-blinded, clinical trial evaluating the same therapeutic regimen primarily with regard to thickness of the retinal nerve fibre layer and low contrast visual acuity.
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Registered trials
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