ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2014
Volumetric contrast-enhanced ultrasound imaging of renal perfusion.
Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Ultrasound imaging of breast tumor perfusion and neovascular morphology.Ultrasound in medicine & biology · 2015Trial
- Progresses and clinical application of super-resolution ultrasound imaging: a narrative review.The ultrasound journal · 2025Review
- Ultrasonographic assessment of renal microcirculation is a new vision for the treatment of intensive care unit associated acute kidney injury.European journal of medical research · 2024Review
- Renal medullary perfusion differs from that in renal cortex in patients with sepsis associated acute kidney injury and correlates with renal function prognosis: A prospective cohort study.Clinical hemorheology and microcirculation · 2024Article
- Evaluation of renal ischemia-reperfusion injury using CEUS in mice.European radiology experimental · 2023Article
- 3-D H-scan ultrasound imaging of relative scatterer size using a matrix array transducer and sparse random aperture compounding.Computers in biology and medicine · 2022Article
- Heart Failure and Cardiorenal Syndrome: A Narrative Review on Pathophysiology, Diagnostic and Therapeutic Regimens-From a Cardiologist's View.Journal of clinical medicine · 2022Review
- Cardiorenal Syndrome: Emerging Role of Medical Imaging for Clinical Diagnosis and Management.Journal of personalized medicine · 2021Review
- Three-dimensional visualization and improved quantification with super-resolution ultrasound imaging - validation framework for analysis of microvascular morphology using a chicken embryo model.Physics in medicine and biology · 2021Article
- Super-Resolution Imaging with Ultrasound for Visualization of the Renal Microvasculature in Rats Before and After Renal Ischemia: A Pilot Study.Diagnostics (Basel, Switzerland) · 2020Article
- Three-dimensional evaluation of microvascular networks using contrast-enhanced ultrasound and microbubble tracking.IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium · 2020Article
- Clinical examination findings as predictors of acute kidney injury in critically ill patients.Acta anaesthesiologica Scandinavica · 2020Observational
- Multiscale quantification of tumor microarchitecture for predicting therapy response using dynamic contrast-enhanced ultrasound imaging.IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium · 2019Article
- Article
- Impact of hydrostatic pressure on phase-change contrast agent activation by pulsed ultrasound.The Journal of the Acoustical Society of America · 2019Article
- Plane wave versus focused transmissions for contrast enhanced ultrasound imaging: the role of parameter settings and the effects of flow rate on contrast measurements.Physics in medicine and biology · 2019Article
- New Ultrasound Techniques Promise Further Advances in AKI and CKD.Journal of the American Society of Nephrology : JASN · 2017Review
- Toward optimization of in vivo super-resolution ultrasound imaging using size-selected microbubble contrast agents.Medical physics · 2017Article
- Perioperative Acute Kidney Injury: Risk Factors and Predictive Strategies.Critical care clinics · 2017Review
- Imaging technologies for monitoring the safety, efficacy and mechanisms of action of cell-based regenerative medicine therapies in models of kidney disease.European journal of pharmacology · 2016Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo determine whether volumetric contrast-enhanced ultrasound (US) imaging has the potential to monitor changes in renal perfusion after vascular injury.
methodsVolumetric contrast-enhanced US uses a series of planar image acquisitions, capturing the nonlinear second harmonic signal from microbubble contrast agents flowing in the vasculature. Tissue perfusion parameters (peak intensity [IPK], time to peak intensity [TPK], wash-in rate [WIR], and area under the curve [AUC]) were derived from time-intensity curve data collected during in vitro flow phantom studies and in vivo animal studies of healthy and injured kidneys. For the flow phantom studies, either the contrast agent concentration was held constant (10 μL/L) with varying volumetric flow rates (10, 20, and 30 mL/min), or the flow rate was held constant (30 mL/min) with varying contrast agent concentrations (5, 10, and 20 μL/L). Animal studies used healthy rats or those that underwent renal ischemia-reperfusion injury. Renal studies were performed with healthy rats while the transducer angle was varied for each volumetric contrast-enhanced US image acquisition (reference or 0°, 45°, and 90°) to determine whether repeated renal perfusion measures were isotropic and independent of transducer position. Blood serum biomarkers and immunohistology were used to confirm acute kidney injury.
resultsFlow phantom results revealed a linear relationship between microbubble concentrations injected into the flow system and the IPK, WIR, and AUC (R(2) > 0.56; P < .005). Furthermore, there was a linear relationship between volume flow rate changes and the TPK, WIR, and AUC (R(2) > 0.77; P < .005). No significant difference was found between the transducer angle during data acquisition and any of the perfusion measures (P > .60). After induction of renal ischemia-reperfusion injury in the rat animal model (n = 4), volumetric contrast-enhanced US imaging of the injured kidney revealed an initial reduction in renal perfusion compared to control animals, followed by progressive recovery of vascular function.
conclusionsVolumetric contrast-enhanced US-based renal perfusion imaging may prove clinically feasible for detecting and monitoring acute kidney injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.