ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2014
Acoustic radiation force for noninvasive evaluation of corneal biomechanical changes induced by cross-linking therapy.
Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01403129 (Early Detection of Keratoconus Using Ultrasound), which is not on this map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Detection of Keratoconus Using Ultrasound
Who cites it
6 citing papers in PubMed.
- In Vivo Safety Evaluation of Acoustic Radiation Force for Optical Coherence Elastography of the Crystalline Lens.Translational vision science & technology · 2025Article
- In-vivo 3D corneal elasticity using air-coupled ultrasound optical coherence elastography.Biomedical optics express · 2019Article
- Ultrasonic Microelastography to Assess Biomechanical Properties of the Cornea.IEEE transactions on bio-medical engineering · 2019Article
- High-Resolution Shear Wave Imaging of the Human Cornea Using a Dual-Element Transducer.Sensors (Basel, Switzerland) · 2018Article
- Application of Elastography for the Noninvasive Assessment of Biomechanics in Engineered Biomaterials and Tissues.Annals of biomedical engineering · 2016Review
- Consideration of corneal biomechanics in the diagnosis and management of keratoconus: is it important?Eye and vision (London, England) · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
objectivesTo noninvasively measure changes in corneal biomechanical properties induced by ultraviolet-activated riboflavin cross-linking therapy using acoustic radiation force (ARF).
methodsCross-linking was performed on the right eyes of 6 rabbits, with the left eyes serving as controls. Acoustic radiation force was used to assess corneal stiffness before treatment and weekly for 4 weeks after treatment. Acoustic power levels were within US Food and Drug Administration guidelines for ophthalmic safety. Strain, determined from ARF-induced displacement of the front and back surfaces of the cornea, was fit to the Kelvin-Voigt model to determine the elastic modulus (E) and coefficient of viscosity (η). The stiffness factor, the ratio of E after treatment to E before treatment, was calculated for treated and control eyes. At the end of 4 weeks, ex vivo thermal shrinkage temperature analysis was performed for comparison with in vivo stiffness measurements. One-way analysis of variance and Student t tests were performed to test for differences in E, η, the stiffness factor, and corneal thickness.
resultsBiomechanical stiffening was immediately evident in cross-linking-treated corneas. At 4 weeks after treatment, treated corneas were 1.3 times stiffer and showed significant changes in E (P= .006) and η (P= .007), with no significant effect in controls. Corneal thickness increased immediately after treatment but did not differ significantly from the pretreatment value at 4 weeks.
conclusionsOur findings demonstrate a statistically significant increase in stiffness in cross-linking-treated rabbit corneas based on in vivo axial stress/strain measurements obtained using ARF. The capacity to noninvasively monitor corneal stiffness offers the potential for clinical monitoring of cross-linking therapy.
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