ArticleBrain research2014
Timing-dependent priming effects of tDCS on ankle motor skill learning.
Article in Brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Transcranial Direct Current Stimulation to Augment Motor Imagery Training: A Systematic Review.The European journal of neuroscience · 2025Pooled it
- Systematic Review of the Impact of Transcranial Direct Current Stimulation on the Neuromechanical Management of Foot and Ankle Physical Performance in Healthy Adults.Frontiers in bioengineering and biotechnology · 2020Pooled it
- Using non-invasive transcranial stimulation to improve motor and cognitive function in Parkinson's disease: a systematic review and meta-analysis.Scientific reports · 2017Pooled it
- Transcranial direct current stimulation enhances delayed retention after 5 days of lower-limb motor skill learning.The Journal of physiology · 2026Trial
- Enhancing astronaut training: effects of transcranial direct current stimulation on manual rendezvous and docking skill acquisition.Journal of neuroengineering and rehabilitation · 2025Trial
- Effects of transcranial electrical stimulation of the cerebellum, parietal cortex, anterior cingulate, and motor cortex on postural adaptation.Scientific reports · 2025Trial
- Timing of high-definition transcranial direct current stimulation to the nondominant primary motor cortex fails to modulate cortical hemodynamic activity and improve motor sequence learning.Journal of neuroengineering and rehabilitation · 2025Trial
- Unraveling Transformative Effects after tDCS and BCI Intervention in Chronic Post-Stroke Patient Rehabilitation-An Alternative Treatment Design Study.Sensors (Basel, Switzerland) · 2023Trial
- Effects of active and sham tDCS on the soleus H-reflex during standing.Experimental brain research · 2023Trial
- Using tDCS to facilitate motor learning in speech production: The role of timing.Cortex; a journal devoted to the study of the nervous system and behavior · 2019Trial
- Harnessing Neuroplasticity: The Role of Priming in Enhancing Post Stroke Motor Function.Restorative neurology and neuroscience · 2026Review
- The Modulatory Effect of tDCS Onset Timing in Alleviating Vigilance Decrement.Brain sciences · 2025Article
- Clinical feasibility of motor hotspot localization based on electroencephalography using convolutional neural networks in stroke.Journal of neuroengineering and rehabilitation · 2025Article
- The Modulatory Effects of Transcranial Alternating Current Stimulation on Brain Oscillatory Patterns in the Beta Band in Healthy Older Adults.Brain sciences · 2024Article
- Simulating tDCS electrode placement to stimulate both M1 and SMA enhances motor performance and modulates cortical excitability depending on current flow direction.Frontiers in neuroscience · 2024Article
- Feasibility and Safety of Sequential Transcranial Direct Current Stimulation and Physical Therapy in Older Adults at Risk of Falling: A Randomized Pilot Study.Archives of rehabilitation research and clinical translation · 2023Article
- Effects of tDCS on Foot Biomechanics: A Narrative Review and Clinical Applications.Bioengineering (Basel, Switzerland) · 2023Review
- Short-term ocular dominance plasticity is not modulated by visual cortex tDCS but increases with length of monocular deprivation.Scientific reports · 2023Article
- Chronic muscle recordings reveal recovery of forelimb function in spinal injured female rats after cortical epidural stimulation combined with rehabilitation and chondroitinase ABC.Journal of neuroscience research · 2022Article
- Motor overflow in the lower limb after stroke: Insights into mechanisms.The European journal of neuroscience · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Transcranial direct current stimulation (tDCS) has gained increasing interest in neurorehabilitation with its ability to modulate cortical excitability, and thereby influence neural plasticity and functional recovery. While the beneficial effects of tDCS on motor learning and function have been recognized, there is no clear consensus regarding the timing of the tDCS priming protocol in relation to the intervention especially with respect to lower limb motor learning. Depending on the time of priming in relation to the training task, the neural mechanisms of priming (gating vs. homeostatic plasticity) are different and thereby subsequently affect motor learning. Hence, the aim of this study was to examine the interaction of tDCS with subsequent vs. concurrent motor learning using an ankle visuomotor skill learning paradigm. Twelve healthy participants were tested under three stimulation conditions: (1) anodal tDCS prior to the motor task (tDCS-before), (2) anodal tDCS during the motor task (tDCS-during) and (3) sham tDCS during the motor task (tDCS-sham). Results revealed that tDCS application during practice of a skilled motor task increased motor performance compared to tDCS applied prior to motor practice. Both tDCS groups demonstrated enhanced motor learning when tested 24 hours after practice. We conclude that the priming effects of tDCS are timing dependent, and maybe a critical regulatory feature in determining outcomes of priming with tDCS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.