ReviewThe oncologist2014
Mild primary hyperparathyroidism: a literature review.
Review in The oncologist, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Efficacy and safety of ultrasound-guided microwave ablation for primary hyperparathyroidism: a dual-centre study.Scientific reports · 2026Article
- Biochemical Profile of and Factors Associated With Recurrence in Primary Hyperparathyroidism.JAMA otolaryngology-- head & neck surgery · 2025Article
- Changes in bone turnover markers and bone mineral density after radiofrequency ablation for mild primary hyperparathyroidism: a prospective cohort study.Quantitative imaging in medicine and surgery · 2024Article
- Diagnostic Value of Four-Dimensional Dynamic Computed Tomography for Primary Hyperparathyroidism in Patients with Low Baseline Parathyroid Hormone Levels.Diagnostics (Basel, Switzerland) · 2023Article
- Comparison of Medical Management versus Parathyroidectomy in Patients with Mild Primary Hyperparathyroidism: A Meta-Analysis.Cancers · 2023Review
- Evolving Role of [Journal of clinical medicine · 2023Article
- Article
- Effect of Parathyroidectomy on Metabolic Homeostasis in Primary Hyperparathyroidism.Journal of clinical medicine · 2022Article
- Surgical management of MILD hyperparathyroidism.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- A study on the causes of operative failures after microwave ablation for primary hyperparathyroidism.European radiology · 2021Article
- Clinical Study on Safety and Efficacy of Microwave Ablation for Primary Hyperparathyroidism.Korean journal of radiology · 2020Article
- Characterization of Calcium Homeostasis in Lithium-Treated Patients Reveals Both Hypercalcaemia and Hypocalcaemia.World journal of surgery · 2020Article
- Mild sporadic primary hyperparathyroidism: high rate of multiglandular disease is associated with lower surgical cure rate.Langenbeck's archives of surgery · 2019Article
- Primary Hyperparathyroidism is Underdiagnosed and Suboptimally Treated in the Clinical Setting.World journal of surgery · 2018Article
- Bone mineral density in primary care patients related to serum calcium concentrations: a longitudinal cohort study from Sweden.Scandinavian journal of primary health care · 2018Article
- Surgery for Primary Hyperparathyroidism with Normal Non-suppressed Parathyroid Hormone can be Both Challenging and Successful.World journal of surgery · 2018Article
- Improving diagnostic recognition of primary hyperparathyroidism with machine learning.Surgery · 2017Article
- Intraoperative parathormone monitoring to predict operative success in patients with normohormonal hyperparathyroidism.Canadian journal of surgery. Journal canadien de chirurgieArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The biochemical profile of classic primary hyperparathyroidism (pHPT) consists of both elevated calcium and parathyroid hormone levels. The standard of care is parathyroidectomy unless prohibited by medical comorbidities. Because more patients are undergoing routine bone density evaluation and neck imaging studies for other purposes, there is a subset of people identified with a biochemically mild form of the pHPT that expresses itself as either elevated calcium or parathyroid hormone levels. These patients often do not fall into the criteria for operation based on the National Institutes of Health consensus guidelines, and they can present a challenge of diagnosis and management. The purpose of this paper is to review the available literature on mild pHPT in an effort to better characterize this patient population and to determine whether patients benefit from parathyroidectomy. Evidence suggests that there are patients with mild pHPT who have overt symptoms that are found to improve after parathyroidectomy. There is also a group of patients with biochemically mild pHPT who are found to progress to classic pHPT over time; however, it is not predictable which group of patients this will be. Early intervention for this group with mild pHPT may prevent progression of bone, psychiatric, and renal complications, and parathyroidectomy has proven safe in appropriately selected patients at high volume centers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.