ArticleJournal of biomechanics2014
Curvature effect on hemodynamic conditions at the inner bend of the carotid siphon and its relation to aneurysm formation.
Article in Journal of biomechanics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- What does computational fluid dynamics tell us about intracranial aneurysms? A meta-analysis and critical review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Pooled it
- Time and architecture: the next two dimensions of microphysiological systems.npj biomedical innovations · 2026Review
- Amplification of Secondary Flow at the Initiation Site of Intracranial Sidewall Aneurysms.Cardiovascular engineering and technology · 2025Article
- Development of an in-vitro model based on patient vessel geometry for simulated use testing in neurointerventional surgery.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Fluid-Structure Interaction Simulations of the Initiation Process of Cerebral Aneurysms.Brain sciences · 2024Article
- Virtual Shape-Editing of Patient-Specific Vascular Models Using Regularized Kelvinlets.IEEE transactions on bio-medical engineering · 2024Article
- Effect of Siphon Morphology on the Risk of C7 Segment Aneurysm Formation : A Case-control CFD Study.Clinical neuroradiology · 2024Article
- Hemodynamic characteristics of vertebrobasilar artery fenestration combined with vertebrobasilar dolichoectasia: a study based on magnetic resonance angiography.American journal of nuclear medicine and molecular imaging · 2024Article
- Carotid tortuosity is associated with extracranial carotid artery aneurysms.Quantitative imaging in medicine and surgery · 2022Article
- Hemodynamic indicators of the formation of tandem intracranial aneurysm based on a vascular restoration algorithm.Frontiers in neurology · 2022Article
- Increased Carotid Siphon Tortuosity Is a Risk Factor for Paraclinoid Aneurysms.Frontiers in neurology · 2022Article
- Hemodynamic and Geometric Risk Factors for In-Stent Restenosis in Patients with Intracranial Atherosclerotic Stenosis.Oxidative medicine and cellular longevity · 2022Article
- Automated landmarking of bends in vascular structures: a comparative study with application to the internal carotid artery.Biomedical engineering online · 2021Review
- Wall shear stress gradient is independently associated with middle cerebral artery aneurysm development: a case-control CFD patient-specific study based on 77 patients.BMC neurology · 2021Article
- The quantitative comparison between high wall shear stress and high strain in the formation of paraclinoid aneurysms.Scientific reports · 2021Article
- Digital Subtraction Angiography Contrast Material Transport as a Direct Assessment for Blood Perfusion of Middle Cerebral Artery Stenosis.Frontiers in physiology · 2021Article
- Case Report: Dynamic Changes in Hemodynamics During the Formation and Progression of Intracranial Aneurysms.Frontiers in cardiovascular medicine · 2021Article
- Current Knowledge of and Perspectives about the Pathogenesis of Blood Blister-like Aneurysms of the Internal Carotid Artery: A Review of the Literature.International journal of medical sciences · 2021Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Although high-impact hemodynamic forces are thought to lead to cerebral aneurysmal change, little is known about the aneurysm formation on the inner aspect of vascular bends such as the internal carotid artery (ICA) siphon where wall shear stress (WSS) is expected to be low. This study evaluates the effect of vessel curvature and hemodynamics on aneurysm formation along the inner carotid siphon. Catheter 3D-rotational angiographic volumes of 35 ICA (10 aneurysms, 25 controls) were evaluated in 3D for radius of curvature and peak curvature of the siphon bend, followed by univariate statistical analysis. Computational fluid dynamic (CFD) simulations were performed on patient-derived models after aneurysm removal and on synthetic variants of increasing curvature. Peak focal siphon curvature was significantly higher in aneurysm bearing ICAs (0.36 ± 0.045 vs. 0.30 ± 0.048 mm(-1), p=0.003), with no difference in global radius of curvature (p=0.36). In CFD simulations, increasing parametric curvature tightness (from 5 to 3mm radius) resulted in dramatic increase of WSS and WSS gradient magnitude (WSSG) on the inner wall of the bend. In patient-derived data, the location of aneurysms coincided with regions of low WSS (<4 Pa) flanked by high WSS and WSSG peaks. WSS peaks correlated with the aneurysm neck. In contrast, control siphon bends displayed low, almost constant, WSS and WSSG profiles with little spatial variation. High bend curvature induces dynamically fluctuating high proximal WSS and WSSG followed by regions of flow stasis and recirculation, leading to local conditions known to induce destructive vessel wall remodeling and aneurysmal initiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.