ArticleAge (Dordrecht, Netherlands)2014
Age-associated alterations of cardiac structure and function in the female F344xBN rat heart.
Article in Age (Dordrecht, Netherlands), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Mitochondrial Dysfunction in HFpEF: Potential Interventions Through Exercise.Journal of cardiovascular translational research · 2025Review
- Interindividual Age-Independent Differences in Human CX43 Impact Ventricular Arrhythmic Risk.Research (Washington, D.C.) · 2023Article
- Heart Failure With Preserved Ejection Fraction: Heterogeneous Syndrome, Diverse Preclinical Models.Circulation research · 2022Review
- Mycobacterium vaccae immunization in rats ameliorates features of age-associated microglia activation in the amygdala and hippocampus.Scientific reports · 2022Article
- Protein acetylation in cardiac aging.Journal of molecular and cellular cardiology · 2021Review
- Sex Differences in Molecular Mechanisms of Cardiovascular Aging.Frontiers in aging · 2021Review
- Sex related differences in the pathogenesis of organ fibrosis.Translational research : the journal of laboratory and clinical medicine · 2020Review
- The role of inflammation in driving left ventricular remodeling in a pre-HFpEF model.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- Zeaxanthin Isolated fromMarine drugs · 2019Article
- Unmasking of oestrogen-dependent changes in left ventricular structure and function in aged female rats: a potential model for pre-heart failure with preserved ejection fraction.The Journal of physiology · 2019Article
- Twist1 was detected in mesenchymal cells of mammary fibroadenoma and invasive components of breast carcinoma in rats.Journal of toxicologic pathology · 2019Article
- Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications.Pharmacological reviews · 2017Review
- Effect of Age, Estrogen Status, and Late-Life GPER Activation on Cardiac Structure and Function in the Fischer344×Brown Norway Female Rat.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection.Pharmacology & therapeutics · 2015Review
- Efficacy of female rat models in translational cardiovascular aging research.Journal of aging research · 2014Review
- Study of Therapeutic Effects of Losartan for Sarcopenia Based on the F344xBN Rat Aging Model.In vivo (Athens, Greece)Article
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7 authors.
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Abstract
The Fischer 344/NNiaHSD × Brown Norway/BiNia F1 (F344xBN) rat model exhibits an increased life span and fewer age-associated pathologies compared to commonly used Fischer 344 (F344). How aging may affect cardiac structure and function in these animals, has to our knowledge, not been investigated. Echocardiography was performed on female F344xBN rats at 6, 26, and 30 months of age using a Phillips 5500 Echocardiography system. Before sacrifice, electrocardiograms were measured in the female F344xBN in order to determine heart rhythm interval changes. Aging was associated with an increase in heart to body weight ratio, cardiomyocyte cross-sectional area, posterior wall thickening, and left ventricle chamber dilatation. Aging was associated with slight evidence of diastolic dysfunction. Alterations in heart rhythm intervals were associated with alterations in the spatial distribution of connexin 43. The incidence of arrhythmias was not different with age; however, valvular dysfunction was increased. These data suggest that aging in the female F344xBN rat heart is associated with changes in cardiac structure as well as function. Further investigation regarding other parameters of cardiac biochemistry and function is needed to better understand the normal compensated cardiovascular aging process in the female F344xBN.
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