ArticleDevelopmental biology2014
Ephrin-mediated restriction of ERK1/2 activity delimits the number of pigment cells in the Ciona CNS.
Article in Developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Orthologs at the Base of the Olfactores Clade.Genes · 2024Review
- Specification of distinct cell types in a sensory-adhesive organ important for metamorphosis in tunicate larvae.PLoS biology · 2024Article
- Article
- ERK signaling dissolves ERF repression condensates in living embryos.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Brain Sensory Organs of the AscidianFrontiers in cell and developmental biology · 2021Review
- TheFrontiers in cell and developmental biology · 2020Article
- Foxg specifies sensory neurons in the anterior neural plate border of the ascidian embryo.Nature communications · 2019Article
- An FGF-driven feed-forward circuit patterns the cardiopharyngeal mesoderm in space and time.eLife · 2018Article
- Article
- T-type Calcium Channel Regulation of Neural Tube Closure and EphrinA/EPHA Expression.Cell reports · 2015Article
- Diverse ETS transcription factors mediate FGF signaling in the Ciona anterior neural plate.Developmental biology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent evidence suggests that ascidian pigment cells are related to neural crest-derived melanocytes of vertebrates. Using live-imaging, we determine a revised cell lineage of the pigment cells in Ciona intestinalis embryos. The neural precursors undergo successive rounds of anterior-posterior (A-P) oriented cell divisions, starting at the blastula 64-cell stage. A previously unrecognized fourth A-P oriented cell division in the pigment cell lineage leads to the generation of the post-mitotic pigment cell precursors. We provide evidence that MEK/ERK signals are required for pigment cell specification until approximately 30min after the final cell division has taken place. Following each of the four A-P oriented cell divisions, ERK1/2 is differentially activated in the posterior sister cells, into which the pigment cell lineage segregates. Eph/ephrin signals are critical during the third A-P oriented cell division to spatially restrict ERK1/2 activation to the posterior daughter cell. Targeted inhibition of Eph/ephrin signals results in, at neurula stages, anterior expansion of both ERK1/2 activation and a pigment cell lineage marker and subsequently, at larval stages, supernumerary pigment cells. We discuss the implications of these findings with respect to the evolution of the vertebrate neural crest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.