Evidence map›Paper›PMID 25062593›Full record

Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2014

Cognitive remediation therapy in adolescents with early-onset schizophrenia: a randomized controlled trial.

Olga Puig, Rafael Penadés, Inmaculada Baeza, Elena De la Serna, Vanessa Sánchez-Gistau, Miquel Bernardo, Josefina Castro-Fornieles

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 32 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 7 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01701609 nacompletednot on this map

Efficacy of a Cognitive Remediation Treatment in Adolescents With Schizophrenia Spectrum Disorders

TypeinterventionalSponsorHospital Clinic of BarcelonaRan2007 to 2013Enrolled50ConditionsSchizophreniaArmsCognitive Remediation Therapy
NCT05577338 nacompletednot on this mapstarted 2018, after this paper: background citation

Neural Mechanism Underlying the Beneficial Effect of Theory of Mind Psychotherapy on Early-onset Schizophrenia: A Randomized Controlled Trial.

TypeinterventionalSponsorThe First Affiliated Hospital of Anhui Medical UniversityRan2018 to 2021Enrolled30ConditionsEarly-onset SchizophreniaArmsTheory of Mind psychotherapy, health education
NCT05911529 nacompletednot on this mapstarted 2023, after this paper: background citation

Motivational Interviewing for Patients With Acute Psychosis

TypeinterventionalSponsorPsychiatric University Hospital, ZurichRan2023 to 2023Enrolled28ConditionsPsychosis, SchizophreniaArmsMotivational Interviewing, Supportive conversations
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 7 syntheses or guidelines pooled it, 90 citations in OpenAlex.

  1. Pooled it
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  3. European Psychiatric Association guidance on assessment of cognitive impairment in schizophrenia.European psychiatry : the journal of the Association of European Psychiatrists · 2022
    Pooled it
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  5. Psychological interventions for psychosis in adolescents.The Cochrane database of systematic reviews · 2020
    Pooled it
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  17. Cognitive impairment in adolescent and adult-onset psychosis: a comparative study.Child and adolescent psychiatry and mental health · 2024
    Article
  18. Article
  19. Practitioner Review: Psychosis in children and adolescents.Journal of child psychology and psychiatry, and allied disciplines · 2023
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Olga PuigHospital Clínic of Barcelona, and with Centro de Investigación Biomédica En Red de Salud Mental (CIBERSAM), Madrid. Electronic address: opuig@clinic.ub.es.
Rafael PenadésUnitat Esquizofrènia Clínic, Hospital Clínic of Barcelona, CIBERSAM, and IDIBAPS.
Inmaculada BaezaHospital Clínic of Barcelona, CIBERSAM, and the Unitar Esquizofrènia Clínic, Spain.
Elena De la SernaHospital Clínic of Barcelona, and with Centro de Investigación Biomédica En Red de Salud Mental (CIBERSAM), Madrid.
Vanessa Sánchez-GistauHospital Clínic of Barcelona, and with Centro de Investigación Biomédica En Red de Salud Mental (CIBERSAM), Madrid.
Miquel BernardoUnitat Esquizofrènia Clínic, Hospital Clínic of Barcelona, CIBERSAM, IDIBAPS, and with the UB.
Josefina Castro-FornielesHospital Clínic of Barcelona, CIBERSAM, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), and with the University of Barcelona (UB).
Centro de Investigación Biomédica en Red de Salud Mental · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveCognitive impairment is an enduring and functionally relevant feature of early-onset schizophrenia (EOS). Cognitive remediation therapy (CRT) improves cognition and functional outcome in adults with schizophrenia, although data in adolescents with EOS remain scarce. The purpose of this study is to examine the efficacy of CRT in improving cognition and functional outcomes in a sample of symptomatically stable but cognitively disabled adolescents with EOS.

methodWe performed a randomized, controlled trial of individually delivered CRT plus treatment-as-usual compared with treatment-as-usual (TAU). Fifty adolescents with EOS were randomly assigned to receive CRT (n = 25) or TAU (n = 25) and were included in an intention-to-treat analysis. Clinical symptoms and cognitive and functional performance were assessed before and after treatment in both groups and after 3 months in the CRT group. Cognitive domains were defined according to the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) consensus battery and averaged in a global cognitive composite score.

resultsAfter CRT, significant improvements were found in verbal memory and executive functions, with medium-to-large effect sizes (ES). The derived cognitive composite score showed an improvement after the treatment, with a large ES. This change was reliable in more than two-thirds of the treated patients. Medium-sized ES were found for improvements after CRT in daily living and adaptive functioning, whereas large ES were observed for improvements in family burden. With the exception of functional gains, these changes were maintained after 3 months.

conclusionCRT appears to be a useful intervention strategy for adolescents with EOS. Cognitive improvements can be achieved through CRT, although further research is warranted to determine the durability of functional gains. Clinical trial registration information-Cognitive Remediation Therapy (CRT) in Adolescents With EOS; www.clinicaltrials.gov; NCT01701609.

Indexed as

CognitionExecutive FunctionSchizophreniaSchizophrenic PsychologyAdolescentAge of OnsetBehavioral SymptomsCognitive Behavioral TherapyFamily HealthFemaleHumansIntelligence TestsMaleMemoryNeuropsychological TestsPsychiatric Status Rating Scalescognitioncognitive remediation therapyCRTearly-onsetfunctional outcome

Identifiers

PMID25062593
OpenAlexW2139671412

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.