Evidence map›Paper›PMID 25062592›Full record

Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2014

Family-focused treatment for adolescents and young adults at high risk for psychosis: results of a randomized trial.

David J Miklowitz, Mary P O'Brien, Danielle A Schlosser, Jean Addington, Kristin A Candan, Catherine Marshall, Isabel Domingues, Barbara C Walsh, Jamie L Zinberg, Sandra D De Silva and 2 more

2 registry-linked trialsOpen access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 83 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 12 pooled it
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01907282 nacompletednot on this map

Prevention Trial of Family Focused Treatment in Youth at Risk for Psychosis

TypeinterventionalSponsorUniversity of California, Los AngelesRan2010 to 2013Enrolled129ConditionsPsychosisArmsFamily Focused Treatment, Enhanced Care
NCT04338152 naactive not recruitingnot on this mapstarted 2021, after this paper: background citation

Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy Trial

TypeinterventionalSponsorUniversity of California, Los AngelesRan2021 to 2026Enrolled220ConditionsPsychotic Disorders, Prodromal Symptoms, Prodromal Schizophrenia, PsychosisArmsFamily Focused Therapy for Clinical High Risk Youth (FFT-CHR), Enhanced Care (EC)
3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 12 syntheses or guidelines pooled it, 190 citations in OpenAlex.

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  6. Psychological interventions for psychosis in adolescents.The Cochrane database of systematic reviews · 2020
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  7. Interventions for prodromal stage of psychosis.The Cochrane database of systematic reviews · 2019
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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

David J MiklowitzUniversity of California, Los Angles (UCLA) School of Medicine, Los Angeles, CA. Electronic address: dmiklowitz@mednet.ucla.edu.
Mary P O'BrienYale University, New Haven, CT.
Danielle A SchlosserUniversity of California, San Francisco, CA.
Jean AddingtonHotchkiss Brain Institute, University of Calgary, Calgary, Alberta.
Kristin A CandanZucker Hillside Hospital, NY.
Catherine MarshallHotchkiss Brain Institute, University of Calgary, Calgary, Alberta.
Isabel DominguesUniversity of California, San Diego.
Barbara C WalshYale University, New Haven, CT.
Jamie L ZinbergUniversity of California, Los Angles (UCLA) School of Medicine, Los Angeles, CA.
Sandra D De SilvaUniversity of California, Los Angles (UCLA) School of Medicine, Los Angeles, CA.
Michelle Friedman-YakoobianMental Health Center Division of Public Psychiatry, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA.
Tyrone D CannonYale University, New Haven, CT.
University of California, Los Angeles · USYale University · USUniversity of Calgary · CABeth Israel Deaconess Medical Center · USUniversity of California San Diego · USUniversity of California, San Francisco · USZucker Hillside Hospital · US

Funding

1/2-Early Intervention for Youth at Risk for Bipolar DisorderR01MH093676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2016
$3.6M
Prevention Trial of Family Focused Treatment in Youth at Risk for PsychosisRC1MH088546 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CANNON, TYRONE D · 2009 to 2010
$970k
Family-Focused Therapy for Youth with Early-Onset Bipolar or Psychotic Disorders R33MH097007 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2014 to 2016
$853k
PRIME to Action: Enhancing Motivation in Recent Onset SchizophreniaK23MH097795 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCHLOSSER, DANIELLE A. · 2013 to 2016
$704k
Family-Focused Treatment for Youth with Early-Onset Bipolar or Psychotic DisorderR21MH097007 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2013
$439k
NIMH NIH HHS 1RC1MH088546NIMH NIH HHS K23 MH097795NIMH NIH HHS R01 MH093676NIMH NIH HHS R01MH093676NIMH NIH HHS R21 MH097007NIMH NIH HHS R33 MH097007NIMH NIH HHS RC1 MH088546
6 · The paper itself

Abstract

objectiveLongitudinal studies have begun to clarify the phenotypic characteristics of adolescents and young adults at clinical high risk for psychosis. This 8-site randomized trial examined whether a 6-month program of family psychoeducation was effective in reducing the severity of attenuated positive and negative psychotic symptoms and enhancing functioning among individuals at high risk.

methodAdolescents and young adults (mean age 17.4 ± 4.1 years) with attenuated positive psychotic symptoms, brief and intermittent psychosis, or genetic risk with functional deterioration were randomly assigned to 18 sessions of family-focused therapy for individuals at clinical high risk (FFT-CHR) in 6 months or 3 sessions of family psychoeducation (enhanced care [EC]). FFT-CHR included psychoeducation about early signs of psychosis, stress management, communication training, and problem-solving skills training, whereas EC focused on symptom prevention. Independent evaluators assessed participants at baseline and 6 months on positive and negative symptoms and social-role functioning.

resultsOf 129 participants, 102 (79.1%) were followed up at 6 months. Participants in FFT-CHR showed greater improvements in attenuated positive symptoms over 6 months than participants in EC (F1,97 = 5.49, p = .02). Negative symptoms improved independently of psychosocial treatments. Changes in psychosocial functioning depended on age: participants more than 19 years of age showed more role improvement in FFT-CHR, whereas participants between 16 and 19 years of age showed more role improvement in EC. The results were independent of concurrent pharmacotherapy.

conclusionInterventions that focus on improving family relationships may have prophylactic efficacy in individuals at high risk for psychosis. Future studies should examine the specificity of effects of family intervention compared to individual therapy of the same duration and frequency. Clinical trial registration information-Prevention Trial of Family Focused Treatment in Youth at Risk for Psychosis; http://clinicaltrials.gov/; NCT01907282.

Indexed as

Family RelationsPsychotic DisordersSelf CareAdolescentAdultConsumer Health InformationEducation, NonprofessionalFamily TherapyFemaleHumansMaleProblem SolvingSocial AdjustmentTreatment OutcomeYoung Adultattenuated psychotic symptomsearly warning signsfamily therapypsychoeducationschizophrenia

Identifiers

PMID25062592
PMCPMC4112074
OpenAlexW2026500345

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.