ArticlePloS one2014
Excitability of the motor cortex in de novo patients with celiac disease.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
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- Sex-specific reference values for total, central, and peripheral latency of motor evoked potentials from a large cohort.Frontiers in human neuroscience · 2023Article
- Celiac Disease and Neurological Manifestations: From Gluten to Neuroinflammation.International journal of molecular sciences · 2022Review
- A comprehensive review of transcranial magnetic stimulation in secondary dementia.Frontiers in aging neuroscience · 2022Review
- Cerebral hemodynamic changes to transcranial Doppler sonography in celiac disease: A pilot study.Frontiers in human neuroscience · 2022Article
- Intracortical and Intercortical Motor Disinhibition to Transcranial Magnetic Stimulation in Newly Diagnosed Celiac Disease Patients.Nutrients · 2021Article
- Preserved central cholinergic functioning to transcranial magnetic stimulation in de novo patients with celiac disease.PloS one · 2021Article
- TMS Correlates of Pyramidal Tract Signs and Clinical Motor Status in Patients with Cervical Spondylotic Myelopathy.Brain sciences · 2020Article
- Update on the Neurobiology of Vascular Cognitive Impairment: From Lab to Clinic.International journal of molecular sciences · 2020Review
- Association of oral dysbiosis with oral cancer development.Oncology letters · 2020Review
- Update on intensive motor training in spinocerebellar ataxia: time to move a step forward?The Journal of international medical research · 2020Article
- Principles of Electrophysiological Assessments for Movement Disorders.Journal of movement disorders · 2020Article
- "Self-Neuroenhancement": The Last Frontier of Noninvasive Brain Stimulation?Journal of clinical neurology (Seoul, Korea) · 2020Article
- The analysis of miRNA expression profiling datasets reveals inverse microRNA patterns in glioblastoma and Alzheimer's disease.Oncology reports · 2019Article
- Adjunct Diagnostic Value of Transcranial Magnetic Stimulation in Mucopolysaccharidosis-Related Cervical Myelopathy: A Pilot Study.Brain sciences · 2019Article
- The Interactive Effect of Tonic Pain and Motor Learning on Corticospinal Excitability.Brain sciences · 2019Article
- Effect of Paired Associative Stimulation on Corticomotor Excitability in Chronic Smokers.Brain sciences · 2019Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCeliac disease (CD) may initially present as a neurological disorder or may be complicated by neurological changes. To date, neurophysiological studies aiming to an objective evaluation of the potential central nervous system involvement in CD are lacking.
objectiveTo assess the profile of cortical excitability to Transcranial Magnetic Stimulation (TMS) in a group of de novo CD patients. MATERIALS AND
methodsTwenty CD patients underwent a screening for cognitive and neuropsychiatric symptoms by means of the Mini Mental State Examination and the Structured Clinical Interview for DSM-IV Axis I Disorders, respectively. Instrumental exams, including electroencephalography and brain computed tomography, were also performed. Cortico-spinal excitability was assessed by means of single and paired-pulse TMS using the first dorsal interosseus muscle of the dominant hand. TMS measures consisted of resting motor threshold, motor evoked potentials, cortical silent period (CSP), intracortical inhibition (ICI) and facilitation (ICF). None of the CD was on gluten-free diet. A group of 20 age-matched healthy controls was used for comparisons.
resultsCD showed a significantly shorter CSP (78.0 vs 125.0 ms, p<0.025), a reduced ICI (0.3 vs 0.2, p<0.045) and an enhanced ICF (1.1 vs 0.7, p<0.042) compared to controls. A dysthymic disorder was identified in five patients. The effect size between dysthymic and non-dysthymic CD patients indicated a low probability of interference with the CSP (Cohen's d -0.414), ICI (-0.278) and ICF (-0.292) measurements.
conclusionA pattern of cortical excitability characterized by "disinhibition" and "hyperfacilitation" was found in CD patients. Immune system dysregulation might play a central role in triggering changes of the motor cortex excitability.
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