ArticleThe ISME journal2015
Microbial degradation of isosaccharinic acid at high pH.
Article in The ISME journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 60 citations in OpenAlex.
- Microbially-Induced Carbonate Precipitation in Low pH Cement; Potential for Self-Healing in Radioactive Waste Geodisposal Systems.ACS omega · 2025Article
- Microbial degradation of citrate mediates sealing of cement cracks under anaerobic conditions relevant to radioactive waste disposal.Npj Materials degradation · 2025Article
- Radioactive waste microbiology: predicting microbial survival and activity in changing extreme environments.FEMS microbiology reviews · 2024Review
- Extremophilic microbial metabolism and radioactive waste disposal.Extremophiles : life under extreme conditions · 2023Review
- pH and microbial community determine the denitrifying activity in the presence of nitrate-containing radioactive waste.Frontiers in microbiology · 2022Article
- Biogenic Sulfidation of U(VI) and Ferrihydrite Mediated by Sulfate-Reducing Bacteria at Elevated pH.ACS earth & space chemistry · 2021Article
- Microbial Degradation of Citric Acid in Low Level Radioactive Waste Disposal: Impact on Biomineralization Reactions.Frontiers in microbiology · 2021Article
- Enhanced microbial degradation of irradiated cellulose under hyperalkaline conditions.FEMS microbiology ecology · 2020Article
- Extensimonas perlucida sp. nov., a Novel Bacterium Isolated from Sludge.Current microbiology · 2020Article
- Hydrogenotrophic Methanogenesis Under Alkaline Conditions.Frontiers in microbiology · 2020Article
- Genomic Insights Into A Novel, Alkalitolerant Nitrogen Fixing Bacteria,Journal of genomics · 2019Article
- The biogeochemical fate of nickel during microbial ISA degradation; implications for nuclear waste disposal.Scientific reports · 2018Article
- Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations.Nature reviews. Genetics · 2018Review
- Whole-Genome Sequence of the Anaerobic Isosaccharinic Acid Degrading Isolate, Macellibacteroides fermentans Strain HH-ZS.Genome biology and evolution · 2017Article
- Floc Formation Reduces the pH Stress Experienced by Microorganisms Living in Alkaline Environments.Applied and environmental microbiology · 2017Article
- Draft Genome Sequences of Four Alkaliphilic Bacteria Belonging to the Anaerobacillus Genus.Genome announcements · 2017Article
- Article
- The enrichment of an alkaliphilic biofilm consortia capable of the anaerobic degradation of isosaccharinic acid from cellulosic materials incubated within an anthropogenic, hyperalkaline environment.FEMS microbiology ecology · 2015Article
- Anoxic Biodegradation of Isosaccharinic Acids at Alkaline pH by Natural Microbial Communities.PloS one · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intermediate-level radioactive waste (ILW), which dominates the radioactive waste inventory in the United Kingdom on a volumetric basis, is proposed to be disposed of via a multibarrier deep geological disposal facility (GDF). ILW is a heterogeneous wasteform that contains substantial amounts of cellulosic material encased in concrete. Upon resaturation of the facility with groundwater, alkali conditions will dominate and will lead to the chemical degradation of cellulose, producing a substantial amount of organic co-contaminants, particularly isosaccharinic acid (ISA). ISA can form soluble complexes with radionuclides, thereby mobilising them and posing a potential threat to the surrounding environment or 'far field'. Alkaliphilic microorganisms sampled from a legacy lime working site, which is an analogue for an ILW-GDF, were able to degrade ISA and couple this degradation to the reduction of electron acceptors that will dominate as the GDF progresses from an aerobic 'open phase' through nitrate- and Fe(III)-reducing conditions post closure. Furthermore, pyrosequencing analyses showed that bacterial diversity declined as the reduction potential of the electron acceptor decreased and that more specialised organisms dominated under anaerobic conditions. These results imply that the microbial attenuation of ISA and comparable organic complexants, initially present or formed in situ, may play a role in reducing the mobility of radionuclides from an ILW-GDF, facilitating the reduction of undue pessimism in the long-term performance assessment of such facilities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.