ArticlePloS one2014
Improving the safety of Staphylococcus aureus polyvalent phages by their production on a Staphylococcus xylosus strain.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
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- Genomic Insights into and Lytic Potential of Native Bacteriophages M8-2 and M8-3 Against Clinically Relevant Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2025Article
- Comparative Genomics of a PolyvalentViruses · 2023Article
- Phage Therapy againstPharmaceutics · 2022Article
- Characterization of a Virally Encoded Flavodoxin That Can Drive Bacterial Cytochrome P450 Monooxygenase Activity.Biomolecules · 2022Article
- Genomic and Functional Characterization of Vancomycin-Resistant Enterococci-Specific Bacteriophages in thePharmaceutics · 2022Article
- Insights into Gene Transcriptional Regulation ofViruses · 2022Article
- Considerations for the Use of Phage Therapy in Clinical Practice.Antimicrobial agents and chemotherapy · 2022Review
- Cross-Genus "Boot-Up" of Synthetic Bacteriophage in Staphylococcus aureus by Using a New and Efficient DNA Transformation Method.Applied and environmental microbiology · 2022Article
- Article
- Isolation and Characterization of a Novel Phage SaGU1 that Infects Staphylococcus aureus Clinical Isolates from Patients with Atopic Dermatitis.Current microbiology · 2021Article
- High efficacy of a characterized lytic bacteriophage in combination with thyme essential oil against multidrug-resistantIranian journal of veterinary research · 2021Article
- Contribution of Podoviridae and Myoviridae bacteriophages to the effectiveness of anti-staphylococcal therapeutic cocktails.Scientific reports · 2020Article
- Identification, Characterization, and Genomic Analysis of NovelInternational journal of molecular sciences · 2020Article
- Phage S144, A New Polyvalent Phage InfectingInternational journal of molecular sciences · 2020Article
- Article
- Phage-Mediated Molecular Detection (PMMD): A Novel Rapid Method for Phage-Specific Bacterial Detection.Viruses · 2020Article
- BioprospectingViruses · 2020Article
- The Perfect Bacteriophage for Therapeutic Applications-A Quick Guide.Antibiotics (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Team1 (vB_SauM_Team1) is a polyvalent staphylococcal phage belonging to the Myoviridae family. Phage Team1 was propagated on a Staphylococcus aureus strain and a non-pathogenic Staphylococcus xylosus strain used in industrial meat fermentation. The two Team1 preparations were compared with respect to their microbiological and genomic properties. The burst sizes, latent periods, and host ranges of the two derivatives were identical as were their genome sequences. Phage Team1 has 140,903 bp of double stranded DNA encoding for 217 open reading frames and 4 tRNAs. Comparative genomic analysis revealed similarities to staphylococcal phages ISP (97%) and G1 (97%). The host range of Team1 was compared to the well-known polyvalent staphylococcal phages phi812 and K using a panel of 57 S. aureus strains collected from various sources. These bacterial strains were found to represent 18 sequence types (MLST) and 14 clonal complexes (eBURST). Altogether, the three phages propagated on S. xylosus lysed 52 out of 57 distinct strains of S. aureus. The identification of phage-insensitive strains underlines the importance of designing phage cocktails with broadly varying and overlapping host ranges. Taken altogether, our study suggests that some staphylococcal phages can be propagated on food-grade bacteria for biocontrol and safety purposes.
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