ReviewPediatric gastroenterology, hepatology & nutrition2014
Clostridium difficile in Children: To Treat or Not to Treat?
Review in Pediatric gastroenterology, hepatology & nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Derivation and validation of clinical prediction models for viral etiologies of acute diarrhea in North American children presenting for emergency care.medRxiv : the preprint server for health sciences · 2026Article
- Comparison of the LuminexJournal of medical microbiology · 2025Article
- Clostridium difficile infection in pediatric patients (Review).Biomedical reports · 2024Review
- Clostridioides difficile infection in infants: a case report and literature review.Gut pathogens · 2023Article
- The incidence and impact of clostridioides difficile infection on transplant outcomes in acute leukemia and MDS after allogeneic hematopoietic cell transplant-a CIBMTR study.Bone marrow transplantation · 2023Article
- Effects of a Novel Infant Formula on the Fecal Microbiota in the First Six Months of Life: The INNOVA 2020 Study.International journal of molecular sciences · 2023Article
- Infection withAccess microbiology · 2021Article
- HighInternational journal of pediatrics · 2020Article
- Gastroenteritis, Hepatitis, Encephalopathy, and Human Herpesvirus 6 Detection in an Immunocompetent Child: Benefits and Risks of Syndromic Multiplex Molecular Panel Testing.The Journal of pediatrics · 2019Article
- The importance of stool tests in diagnosis and follow-up of gastrointestinal disorders in children.Turk pediatri arsivi · 2019Review
- Antibiotic treatment and stewardship in the era of microbiota-oriented diagnostics.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Clostridium difficile infection in the Lao People's Democratic Republic: first isolation and review of the literature.BMC infectious diseases · 2017Review
- Description and validation of a new automated surveillance system for Clostridium difficile in Denmark.Epidemiology and infection · 2017Article
- Gut associated metabolites and their roles inGut microbesArticle
- An Updated Review of Clostridium difficile Treatment in Pediatrics.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clostridium difficile infection has been increasing since 2000 in children and in adults. Frequent antibiotics use, comorbidity, and the development of hypervirulent strains have increased the risk of infection. Despite the high carriage rates of C. difficile, infants rarely develop clinical infection. Discontinuing antibiotics and supportive management usually leads to resolution of disease. Antibiotics use should be stratified depending on the patient's age and severity of the disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.