ArticleNeuroImage. Clinical2014
General and specific effects of early-life psychosocial adversities on adolescent grey matter volume.
Article in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Application of a diathesis-stress model to the interplay of cortical structural development and emerging depression in youth.Clinical psychology review · 2020Pooled it
- Early-life and pubertal stress differentially modulate grey matter development in human adolescents.Scientific reports · 2018Trial
- Timing and tempo of puberty and neurodevelopment following adversity: A registered report.Developmental cognitive neuroscience · 2026Article
- Relationships between serotonin 1A receptor DNA methylation, self-reported history of childhood abuse and gray matter volume in major depression.Journal of affective disorders · 2024Article
- Reciprocal relationships between stress and depressive symptoms: the essential role of the nucleus accumbens.Psychological medicine · 2024Article
- Complex Intersections Between Adverse Childhood Experiences and Negative Life Events Impact the Phenome of Major Depression.Psychology research and behavior management · 2024Article
- Observed Parenting and Adolescent Brain Structure.Developmental neuropsychology · 2023Article
- The effects of sexual abuse on female adolescent brain structures.Scandinavian journal of child and adolescent psychiatry and psychology · 2023Article
- Early Life Stress AffectsInternational journal of molecular sciences · 2022Review
- Adverse childhood experiences and cognitive disability in the 2019 United States behavioral risk factor surveillance system.Preventive medicine reports · 2022Article
- Prenatal and Childhood Adverse Events and Child Brain Morphology: A Population-Based Study.Aperture neuro · 2022Article
- Childhood Threat Is Associated With Lower Resting-State Connectivity Within a Central Visceral Network.Frontiers in psychology · 2022Article
- A meta-analysis of brain morphometric aberrations in adolescents who experienced childhood trauma.Frontiers in human neuroscience · 2022Article
- The association between latent trauma and brain structure in children.Translational psychiatry · 2021Article
- Evaluation of the Effects of Developmental Trauma on Neurotransmitter Systems Using Functional Molecular Imaging.International journal of molecular sciences · 2021Article
- Investigating the effects of cerebellar transcranial direct current stimulation on saccadic adaptation and cortisol response.Cerebellum & ataxias · 2021Article
- A Narrative Review of Methodological Considerations in Magnetic Resonance Imaging of Offspring Brain Development and the Influence of Parenting.Frontiers in human neuroscience · 2021Review
- Mood and neural responses to social rejection do not seem to be altered in resilient adolescents with a history of adversity.Development and psychopathology · 2020Article
- Depressogenic self-schemas are associated with smaller regional grey matter volume in never-depressed preadolescents.NeuroImage. Clinical · 2020Article
- Neurocognitive Precursors of Substance Misuse Corresponding to Risk, Resistance, and Resilience Pathways: Implications for Prevention Science.Frontiers in psychiatry · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Exposure to childhood adversities (CA) is associated with subsequent alterations in regional brain grey matter volume (GMV). Prior studies have focused mainly on severe neglect and maltreatment. The aim of this study was to determine in currently healthy adolescents if exposure to more common forms of CA results in reduced GMV. Effects on brain structure were investigated using voxel-based morphometry in a cross-sectional study of youth recruited from a population-based longitudinal cohort. 58 participants (mean age = 18.4) with (n = 27) or without (n = 31) CA exposure measured retrospectively from maternal interview were included in the study. Measures of recent negative life events (RNLE) recorded at 14 and 17 years, current depressive symptoms, gender, participant/parental psychiatric history, current family functioning perception and 5-HTTLPR genotype were covariates in analyses. A multivariate analysis of adversities demonstrated a general association with a widespread distributed neural network consisting of cortical midline, lateral frontal, temporal, limbic, and cerebellar regions. Univariate analyses showed more specific associations between adversity measures and regional GMV: CA specifically demonstrated reduced vermis GMV and past psychiatric history with reduced medial temporal lobe volume. In contrast RNLE aged 14 was associated with increased lateral cerebellar and anterior cingulate GMV. We conclude that exposure to moderate levels of childhood adversities occurring during childhood and early adolescence exerts effects on the developing adolescent brain. Reducing exposure to adverse social environments during early life may optimize typical brain development and reduce subsequent mental health risks in adult life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.