ArticleMolecular metabolism2014
Stress- and diet-induced fat gain is controlled by NPY in catecholaminergic neurons.
Article in Molecular metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Effects of meal timing on changes in circulating epinephrine, norepinephrine, and acylated ghrelin concentrations: a pilot study.Nutrition & diabetes · 2017Trial
- Sex-Specific Role of NPVF Signalling in Homeostatic Control.Biomolecules · 2026Article
- Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance.Nature metabolism · 2026Article
- Association of cerebrospinal fluid NPY with peripheral ApoA: a moderation effect of BMI.Nutrition & metabolism · 2024Article
- Chronic stress promotes gastric cancer progression via the adrenoceptor beta 2/PlexinA1 pathway.Cell stress & chaperones · 2024Article
- Adrenergic modulation of melanocortin pathway by hunger signals.Nature communications · 2023Article
- Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity.Nature communications · 2021Article
- Effect of Cold Stress on Neurobehavioral and Physiological Parameters in Rats.Frontiers in physiology · 2021Article
- Berberine for Appetite Suppressant and Prevention of Obesity.BioMed research international · 2020Article
- Afferent neuropeptide Y projections to the ventral tegmental area in normal-weight male Wistar rats.The Journal of comparative neurology · 2019Article
- Transcriptional changes in the hypothalamus, pituitary, and mammary gland underlying decreased lactation performance in mice under heat stress.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Shared Autonomic Pathways Connect Bone Marrow and Peripheral Adipose Tissues Across the Central Neuraxis.Frontiers in endocrinology · 2019Article
- Chronic stress increases susceptibility to food addiction by increasing the levels of DR2 and MOR in the nucleus accumbens.Neuropsychiatric disease and treatment · 2019Article
- Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling.Nature communications · 2018Article
- Diet-induced obesity suppresses cortical bone accrual by a neuropeptide Y-dependent mechanism.International journal of obesity (2005) · 2018Article
- Peripherally Administered YFrontiers in pharmacology · 2018Article
- Postnatal treatment with metyrapone attenuates the effects of diet-induced obesity in female rats exposed to early-life stress.American journal of physiology. Endocrinology and metabolism · 2017Article
- Posttraumatic stress disorder: A metabolic disorder in disguise?Experimental neurology · 2016Review
- The hunger games of skeletal metabolism.BoneKEy reports · 2014Review
- Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropeptide Y (NPY) and noradrenaline are commonly co-expressed in sympathetic neurons. Both are key regulators of energy homeostasis and critical for stress-coping. However, little is known about the specific function of NPY in the catecholaminergic system in these regulations. Here we show that mice with NPY expression only in the noradrenergic and adrenergic cells of the catecholaminergic system (catNPY) exhibited exacerbated diet-induced obesity, lower body and brown adipose tissue temperatures compared to WT and NPY(-/-) mice under a HFD. Furthermore, chronic stress increased adiposity and serum corticosterone level in WT but not NPY(-/-) mice. Re-introducing NPY specifically to the catecholaminergic system in catNPY mice restored stress responsiveness associated with increased respiratory exchange ratio and decreased liver pACC to tACC ratio. These results demonstrate catecholaminergic NPY signalling is critical in mediating diet- and chronic stress-induced fat gain via effects on diet-induced thermogenesis and stress-induced increases in corticosterone levels and lipogenic capacity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.