ArticleMolecular metabolism2014
A link between hepatic glucose production and peripheral energy metabolism via hepatokines.
Article in Molecular metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 61 citations in OpenAlex.
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- A caveolin-1 dependent glucose-6-phosphatase trafficking contributes to hepatic glucose production.Molecular metabolism · 2023Article
- New uses for an old remedy: Digoxin as a potential treatment for steatohepatitis and other disorders.World journal of gastroenterology · 2023Review
- Association of the Non-Alcoholic Fatty Liver Disease Fibrosis Score with subclinical myocardial remodeling in patients with type 2 diabetes: A cross-sectional study in China.Journal of diabetes investigation · 2021Article
- Angiopoietin-Like Growth Factor Involved in Leptin Signaling in the Hypothalamus.International journal of molecular sciences · 2021Article
- New Horizons in Microbiota and Metabolic Health Research.The Journal of clinical endocrinology and metabolism · 2021Article
- The absence of hepatic glucose-6 phosphatase/ChREBP couple is incompatible with survival in mice.Molecular metabolism · 2021Article
- Hepatic Carbohydrate Response Element Binding Protein Activation Limits Nonalcoholic Fatty Liver Disease Development in a Mouse Model for Glycogen Storage Disease Type 1a.Hepatology (Baltimore, Md.) · 2020Article
- Investigating the Role of Myeloperoxidase and Angiopoietin-like Protein 6 in Obesity and Diabetes.Scientific reports · 2020Observational
- Elevated Circulating Fetuin-B Levels Are Associated with Insulin Resistance and Reduced by GLP-1RA in Newly Diagnosed PCOS Women.Mediators of inflammation · 2020Article
- Glucose-6-Phosphate Regulates Hepatic Bile Acid Synthesis in Mice.Hepatology (Baltimore, Md.) · 2019Article
- Glucose-6 Phosphate, A Central Hub for Liver Carbohydrate Metabolism.Metabolites · 2019Review
- Hepatic stress associated with pathologies characterized by disturbed glucose production.Cell stress · 2019Review
- Long non-coding RNA H19 inhibition promotes hyperglycemia in mice by upregulating hepatic FoxO1 levels and promoting gluconeogenesis.Journal of molecular medicine (Berlin, Germany) · 2019Article
- Intracellular lipids are an independent cause of liver injury and chronic kidney disease in non alcoholic fatty liver disease-like context.Molecular metabolism · 2018Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes is characterized by a deterioration of glucose tolerance, which associates insulin resistance of glucose uptake by peripheral tissues and increased endogenous glucose production. Here we report that the specific suppression of hepatic glucose production positively modulates whole-body glucose and energy metabolism. We used mice deficient in liver glucose-6 phosphatase that is mandatory for endogenous glucose production. When they were fed a high fat/high sucrose diet, they resisted the development of diabetes and obesity due to the activation of peripheral glucose metabolism and thermogenesis. This was linked to the secretion of hepatic hormones like fibroblast growth factor 21 and angiopoietin-like factor 6. Interestingly, the deletion of hepatic glucose-6 phosphatase in previously obese and insulin-resistant mice resulted in the rapid restoration of glucose and body weight controls. Therefore, hepatic glucose production is an essential lever for the control of whole-body energy metabolism during the development of obesity and diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.